For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
6
views
22
references
 Top references
cited by
25
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      3,467
      similar
       All similar
      • Record: found
      • Abstract: not found
      • Article: not found

      The effects of concurrent Coenzyme Q10, L-carnitine supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial

      Author(s): 1 , 2 , 1 , 2 , 3 , 4 , 1 , 2
      Publication date Created:
      Publication date (Electronic):
      Journal: Cephalalgia
      Publisher: SAGE Publications

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The present study aimed to determine the effects of combined supplementation of Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders marker and migraine symptoms among migraine patients.

          Related collections

          Most cited references22

          • Record: found
          • Abstract: found
          • Article: not found

          The epidemiology, burden, and comorbidities of migraine.

          Marcelo E. Bigal, Richard Lipton (2009)
          We describe the epidemiology and comorbidities of migraine, which affects 12% of adults in occidental countries. Prevalence is three times higher in women, but 6% of men are affected, making it the most prevalent neurologic disorder in men. Although migraine is a remarkably common cause of temporary disability, many migraineurs have never consulted a physician for the problem. Many disorders are comorbid with migraine. For some such as depression, the association has been well described, but for others, the relationship has been recently suggested, such as in the case of clinical and subclinical vascular brain lesions and coronary heart disease.
          Article 0 comments Cited 82 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

            B Frei, Manho Kim, James Ames (1990)
            It is well known that ubiquinone-10 (coenzyme Q10, ubiquinone 50) acts as an electron carrier of the respiratory chain in mitochondria. In this paper we show that ubiquinol-10, the reduced form of ubiquinone-10, also efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as alpha-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under our experimental conditions. In contrast to alpha-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. We also show that ubiquinol-10 spares alpha-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol-10, like alpha-tocopherol, does not interact with reduced glutathione. Our data together with previous work on the antioxidant function of ubiquinol reported in the literature strongly suggest that ubiquinol-10 is an important physiological lipid-soluble antioxidant.
            Article 0 comments Cited 72 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.

              P Sándor, A Fumal, U Saenger … (2005)
              Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.
              Article 0 comments Cited 64 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Title: Cephalalgia
                Abbreviated Title: Cephalalgia
                Publisher: SAGE Publications
                ISSN (Print): 0333-1024
                ISSN (Electronic): 1468-2982
                Publication date Created: October 08 2018
                Publication date Created: April 2019
                Publication date (Electronic): January 06 2019
                Publication date (Print): April 2019
                Volume: 39
                Issue: 5
                Pages: 648-654
                Affiliations
                [1 ]Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
                [2 ]Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
                [3 ]Neuroscience Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
                [4 ]Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
                Article
                DOI: 10.1177/0333102418821661
                PubMed ID: 30612463
                SO-VID: c4f3788d-5503-4933-8bfa-250b9b927eb3
                Copyright © © 2019
                License:

                http://journals.sagepub.com/page/policies/text-and-data-mining-license

                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content3,467

                See all similar

                Cited by25

                See all cited by

                Most referenced authors313

                See all reference authors