HIV pre-exposure prophylaxis in men who have sex with men and transgender women: a secondary analysis of a phase 3 randomised controlled efficacy trial.

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Abstract

For maximum effect pre-exposure prophylaxis should be targeted to the subpopulations that account for the largest proportion of infections (population-attributable fraction [PAF]) and for whom the number needed to treat (NNT) to prevent infection is lowest. We aimed to estimate the PAF and NNT of participants in the iPrEx (Pre-Exposure Prophylaxis Initiative) trial.

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Journal

Journal ID (iso-abbrev): Lancet Infect Dis

Title: The Lancet. Infectious diseases

Publisher: Elsevier BV

ISSN (Electronic): 1474-4457

ISSN (Print): 1473-3099

Publication date (Electronic): Jun 2014

Volume: 14

Issue: 6

Affiliations

[1 ] Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: susan.buchbinder@sfdph.org.

[2 ] Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

[3 ] Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.

[4 ] Gladstone Institute of Virology and Immunology, San Francisco, CA, USA.

[5 ] Investigaciones Médicas en Salud, Lima, Peru.

[6 ] Fenway Community Health, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.

[7 ] University of California, San Francisco, CA, USA; Gladstone Institute of Virology and Immunology, San Francisco, CA, USA.

Article

Publisher Item ID: S1473-3099(14)70025-8 Mid ID: NIHMS600835

DOI: 10.1016/S1473-3099(14)70025-8

PMC ID: 4133171

PubMed ID: 24613084

SO-VID: c4fc7cac-7f00-4a29-9de3-ab23aa8d3a2d

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