Ischemia, Hypoxia and Oxidative Stress in Bladder Outlet Obstruction and Bladder Overdistention Injury.

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Abstract

Ischemia and the accompanied hypoxia significantly impair the function of the urinary bladder, which is further damaged by ischemia/reperfusion (I/R) injury following the re-establishment of the blood supply. Current evidences have confirmed that blood flow of the bladder is decreased by bladder outlet obstruction (BOO) and acute overdistention and that functional impairment of the urinary bladder following chronic BOO and acute overdistention might partly come from tissue ischemia and ischemia/reperfusion injury. Antioxidants, free radical scavengers or substances inhibiting I/R injury may reduce bladder damages caused by BOO or overdistention.

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Author and article information

Journal

Journal ID (iso-abbrev): Low Urin Tract Symptoms

Title: Lower urinary tract symptoms

Publisher: Wiley

ISSN: 1757-5664

ISSN (Print): 1757-5664

Publication date (Electronic): Mar 2012

Volume: 4 Suppl 1

Affiliations

[1 ] Division of Urology, Department of Surgery, Taipei Veterans General Hospital; Department of Urology, School of Medicine, and Shu-Tien Urological Science Research Center, National Yang-Ming University, Taipei, TaiwanDepartment of Urology, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Article

DOI: 10.1111/j.1757-5672.2011.00134.x

PubMed ID: 26676697

SO-VID: c580aad5-e8a5-42b7-b31c-1d7095216f22

History

Keywords: urinary bladder,reperfusion injury,oxidative stress,ischemia

Data availability:

Keywords: urinary bladder, reperfusion injury, oxidative stress, ischemia

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