For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
28
views
27
references
 Top references
cited by
22
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      341
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Association of Left Atrial Volume With Mortality Among ESRD Patients With Left Ventricular Hypertrophy Referred for Kidney Transplantation

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Left ventricular hypertrophy (LVH) is common in patients with end-stage renal disease (ESRD) and an independent risk factor for premature cardiovascular death. Left atrial volume (LAV), measured using echocardiography, predicts death in patients with ESRD. Cardiovascular magnetic resonance (CMR) imaging is a volume-independent method of accurately assessing cardiac structure and function in patients with ESRD.

          Study Design

          Single-center prospective observational study to assess the determinants of all-cause mortality, particularly LAV, in a cohort of ESRD patients with LVH, defined using CMR imaging.

          Setting & Participants

          201 consecutive ESRD patients with LVH (72.1% men; mean age, 51.6 ± 11.7 years) who had undergone pretransplant cardiovascular assessment were identified using CMR imaging between 2002-2008. LVH was defined as left ventricular mass index >84.1 g/m 2 (men) or >74.6 g/m 2 (women) based on published normal left ventricle dimensions for CMR imaging. Maximal LAV was calculated using the biplane area-length method at the end of left ventricle systole and corrected for body surface area.

          Predictors

          CMR abnormalities, including LAV.

          Outcome

          All-cause mortality.

          Results

          54 patients died (11 after transplant) during a median follow-up of 3.62 years. Median LAV was 30.4 mL/m 2 (interquartile range, 26.2-58.1). Patients were grouped into high (median or higher) or low (less than median) LAV. There were no significant differences in heart rate and mitral valve Doppler early to late atrial peak velocity ratio. Increased LAV was associated with higher mortality. Kaplan-Meier survival analysis showed poorer survival in patients with higher LAV (log rank P = 0.01). High LAV and left ventricular systolic dysfunction conferred similar risk and were independent predictors of death using multivariate analysis.

          Limitations

          Only patients undergoing pretransplant cardiac assessment are included. Limited assessment of left ventricular diastolic function.

          Conclusions

          Higher LAV and left ventricular systolic dysfunction are independent predictors of death in ESRD patients with LVH.

          Related collections

          Most cited references27

          • Record: found
          • Abstract: found
          • Article: not found

          Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.

          Bengt C Fellström, Alan Jardine, Roland E Schmieder … (2009)
          Statins reduce the incidence of cardiovascular events in patients at high cardiovascular risk. However, a benefit of statins in such patients who are undergoing hemodialysis has not been proved. We conducted an international, multicenter, randomized, double-blind, prospective trial involving 2776 patients, 50 to 80 years of age, who were undergoing maintenance hemodialysis. We randomly assigned patients to receive rosuvastatin, 10 mg daily, or placebo. The combined primary end point was death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. Secondary end points included death from all causes and individual cardiac and vascular events. After 3 months, the mean reduction in low-density lipoprotein (LDL) cholesterol levels was 43% in patients receiving rosuvastatin, from a mean baseline level of 100 mg per deciliter (2.6 mmol per liter). During a median follow-up period of 3.8 years, 396 patients in the rosuvastatin group and 408 patients in the placebo group reached the primary end point (9.2 and 9.5 events per 100 patient-years, respectively; hazard ratio for the combined end point in the rosuvastatin group vs. the placebo group, 0.96; 95% confidence interval [CI], 0.84 to 1.11; P=0.59). Rosuvastatin had no effect on individual components of the primary end point. There was also no significant effect on all-cause mortality (13.5 vs. 14.0 events per 100 patient-years; hazard ratio, 0.96; 95% CI, 0.86 to 1.07; P=0.51). In patients undergoing hemodialysis, the initiation of treatment with rosuvastatin lowered the LDL cholesterol level but had no significant effect on the composite primary end point of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. (ClinicalTrials.gov number, NCT00240331.) 2009 Massachusetts Medical Society
          Article 0 comments Cited 454 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden.

            Teresa Tsang, Marion Barnes, Bernard Gersh … (2002)
            Left ventricular (LV) diastolic dysfunction is prevalent in the community. Current assessment of diastolic function can be complex, involving Doppler evaluation of an array of hemodynamic data. The relation between left atrial (LA) volume and diastolic function, and between LA volume and cardiovascular risk and disease burden are not well known. In the present prospective study of 140 adults, mean age 58 +/- 19 years, referred for a clinically-indicated echocardiogram and in sinus rhythm, with no history of atrial arrhythmias or valvular heart disease, we determined the LA volume, LV diastolic function status, cardiovascular risk score (based on age, gender, history of systemic hypertension, diabetes mellitus, hyperlipidemia, and smoking), and cardiovascular disease burden (based on confirmed vascular disease, congestive heart failure, and transient ischemic attack or stroke). LA volume was found to correlate positively with age, body surface area, cardiovascular risk score, LV end-diastolic and end-systolic dimensions, LV mass, diastolic function grade, tissue Doppler E/E', tricuspid regurgitation velocity, and negatively with LV ejection fraction (all p <0.006). In a multivariate clinical model, LA volume indexed to body surface area (indexed LA volume) was independently associated with cardiovascular risk score (p <0.001), congestive heart failure (p = 0.014), vascular disease (p = 0.012), transient ischemic attack or stroke (p = 0.021), and history of smoking (p = 0.008). In a clinical and echocardiographic model, indexed LA volume was strongly associated with diastolic function grade (p <0.001), independent of LV ejection fraction, age, gender, and cardiovascular risk score. In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden.
            Article 0 comments Cited 202 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady-state free precession imaging sequences.

              Holger Thiele, Khaled Alfakih, Jessica Ridgway … (2003)
              To establish normal ranges of left ventricular (LV) and right ventricular (RV) dimensions as determined by the current pulse sequences in cardiac magnetic resonance imaging (MRI). Sixty normal subjects (30 male and 30 female; age range, 20-65) were examined; both turbo gradient echo (TGE) and steady-state free precession (SSFP) pulse sequences were used to obtain contiguous short-axis cine data sets from the ventricular apex to the base of the heart. The LV and RV volumes and LV mass were calculated by modified Simpson's rule. Normal ranges were established and indexed to both body surface area (BSA) and height. There were statistically significant differences in the measurements between the genders and between TGE and SSFP pulse sequences. For TGE the LV end-diastolic volume (EDV)/BSA (mL/m(2)) in males was 74.4 +/- 14.6 and in females was 70.9 +/- 11.7, while in SSFP in males it was 82.3 +/- 14.7 and in females it was 77.7 +/- 10.8. For the TGE the LV mass/BSA (g/m(2)) in males was 77.8 +/- 9.1 and in females it was 61.5 +/- 7.5, while in SSFP in males it was 64.7 +/- 9.3 and in females it was 52.0 +/- 7.4. For TGE the RV EDV/BSA (mL/m(2)) in males was 78.4 +/- 14.0 and in females it was 67.5 +/- 12.7, while in SSFP in males it was 86.2 +/- 14.1 and in females it was 75.2 +/- 13.8. We have provided normal ranges that are gender specific as well as data that can be used for age-specific normal ranges for both SSFP and TGE pulse sequences. Copyright 2003 Wiley-Liss, Inc.
              Article 0 comments Cited 146 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Am J Kidney Dis
                Journal ID (iso-abbrev): Am. J. Kidney Dis
                Title: American Journal of Kidney Diseases
                Publisher: W.B. Saunders
                ISSN (Print): 0272-6386
                ISSN (Electronic): 1523-6838
                Publication date PMC-release: June 2010
                Publication date (Print): June 2010
                Volume: 55
                Issue: 6
                Pages: 1088-1096
                Affiliations
                [1 ]BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK
                [2 ]Department of Renal Medicine, Western Infirmary, Glasgow, UK
                [3 ]Department of Cardiology, Western Infirmary, Glasgow, UK
                Author notes
                [* ]Address correspondence to Rajan K. Patel, MBChB, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow, G12 8TA UK r.patel@ 123456clinmed.gla.ac.uk
                Article
                Publisher ID: YAJKD53320
                DOI: 10.1053/j.ajkd.2009.12.033
                PMC ID: 2900178
                PubMed ID: 20346559
                SO-VID: c6546ae1-fff2-45aa-8b32-0687cf6e791f
                Copyright © © 2010 Elsevier Inc.
                License:

                This document may be redistributed and reused, subject to certain conditions.

                History
                Date received : 18 August 2009
                Date accepted : 11 December 2009
                Categories
                Subject: Original Investigation
                Subject: Transplantation

                ScienceOpen disciplines: Nephrology
                Keywords: left atrial volume,end-stage renal disease,cardiovascular magnetic resonance imaging (mri),left ventricular hypertrophy
                Data availability:
                ScienceOpen disciplines: Nephrology
                Keywords: left atrial volume, end-stage renal disease, cardiovascular magnetic resonance imaging (mri), left ventricular hypertrophy

                Comments

                Comment on this article

                scite_

                Similar content341

                See all similar

                Cited by22

                See all cited by

                Most referenced authors1,336

                See all reference authors