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      Hiperplasia epitelial focal. Presentación de un caso Translated title: Focal Epithelial Hyperplasia. A Case Report

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          Abstract

          La hiperplasia epitelial focal, conocida también como enfermedad de Heck, es relativamente rara; ocurre en niños y adolescentes. Se presenta el caso de una paciente de 20 años que fue atendida en al Hospital Universitario Manuel Ascunce Domenech, de Camagüey, por presentar lesiones papulares de diez meses de evolución. Se descartaron otras enfermedades virales, pero se concluyó por estudios histológicos que se trataba de la enfermdedad de Heck, la cual es conocida entre los odontólogos, pero poco por pediatras, internistas y dermatólogos. Por su etiología, muchos casos tienen relación con la infección por el virus del papiloma humano. El tratamiento, cuando la enfermedad progresa, puede realizarse con excisión, tratarse con láser o crioterapia. En esta paciente se empleó el último procedimiento, con buenos resultados pues se encuentra totalmente asintomática.

          Translated abstract

          Focal epithelial hyperplasia, also known as Heck’s disease, is relatively rare, occurring mostly in children and adolescents. A case of a 20 year-old female patient treated at the Manuel Ascunce Domenech University Hospital in Camagüey due to papular lesions, which had evolved for ten months, is presented. Other viral diseases were ruled out; however based on histological studies, it was concluded that she suffered from Heck disease, which is frequently treated by dentists, but little known among pediatricians, internists and dermatologists. Because of its etiology, many cases are related to human papilloma virus infection. When the disease evolves, treatment can involve excision, laser surgery or cryotherapy. The latter method was used in this patient with satisfactory results, as she is completely asymptomatic.

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          Most cited references20

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          Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia.

          To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Prospective and retrospective observational study. Dermatology outpatient clinic in a general hospital. Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. None. Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
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            Human papillomavirus infections: epidemiology, pathogenesis, and host immune response.

            S Tyring (2000)
            Human papillomaviruses (HPVs) are ubiquitous and often cause lesions on the skin that come to the attention of the dermatologist. Skin lesions, or warts, often occur on the hands or soles of the feet and can cause embarrassment or discomfort. Genital HPV infections are transmitted by sexual contact. Infections associated with some HPV types have a high risk of progressing to carcinoma. This review discusses the molecular biology and genetics of human papillomaviruses and provides an overview of the virology, pathology, clinical manifestations, and host immune response to infection.
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              Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia.

              Focal epithelial hyperplasia (FEH) is a rare oral HPV-related disease, highly prevalent in certain ethnic communities. A previous study found 7.5% prevalence among school children from the Indian community Embera-Chami in Colombia.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                ms
                MediSur
                Medisur
                Facultad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas Provincia de Cienfuegos. (Cienfuegos )
                1727-897X
                February 2014
                : 12
                : 1
                : 100-105
                Affiliations
                [1 ] Hospital Universitario Manuel Ascunce Domenech Cuba
                Article
                S1727-897X2014000100012
                c795cf38-c4bb-486a-8176-467e79ce0712

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Cuba

                Self URI (journal page): http://scielo.sld.cu/scielo.php?script=sci_serial&pid=1727-897X&lng=en
                Categories
                HEALTH CARE SCIENCES & SERVICES

                Health & Social care
                focal epithelial hyperplasia,therapeutics,case reports,hiperplasia epitelial focal,terapéutica,informes de casos

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