Alteration of mineral element status of rodents under combined group B vitamin deficiency

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Abstract

Abstract. Alterations in mineral element status have been assessed under the combined nutritional deficiency of B 1 , B 2 , and B 6 vitamins in rat and murine in vivo models. Female Wistar (W) and hybrids of the 1 st generation of Dark Agouti and Wistar (DA×W) strains, as well as female BALB/c and DBCB tetrahybrid mice were used. Animals were fed with a balanced diet (control groups) according to AIN93M or lacking vitamins B 1 , B 2 , B 6 (experimental groups) for 5 weeks. The level of essential and toxic mineral elements has been estimated in kidneys by ICP-MS. DA×W rats compared to W and DBCB mice compared to BALB/c were more sensitive to the development of B-vitamin deficiency as assessed by the B-vitamin sufficiency markers. The content of Mg, Сu, Zn, and Cr was decreased, while Cs level was increased in the kidneys of the rats of the experimental groups. In mice, group B vitamin deficiency resulted in reduced Mg, Cu, Zn, Cr, Cd, and Pb content, and excessive Cs accumulation. Some of these biomarkers are supposed to be used in pre-clinical evaluation of the effectiveness of new vitamin dietary supplements, as well as studies of various vitamin interactions. 

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Characterization of silver nanoparticles synthesized by using marine isolate Streptomyces albidoflavus.

Girija Shankar Guntuku, Sudheer Kumar Yannam, Reddy Shetty Prakasham … (2012)

Silver nanoparticles production by the green chemistry approach was investigated using an isolated marine actinomycetes strain. The isolated strain was identified as Streptomyces albidoflavus based on chemotaxonomic and ribotyping properties. The strain revealed production of silver nanoparticles both extracellular and intracellularly. Surface Plasmon Resonance analysis with the function of time revealed that particle synthesis by this strain is reaction time dependent. The produced particles were spherical shaped and monodispersive in nature and showed a single surface plasmon resonance peak at 410 nm. Size distribution histograms indicated production of 10-40- nm-size nanoparticles with a mean size of 14.5 nm. FT-IR spectra of nanopartilces showed N-H, C-H, and C-N stretching vibrations, denoting the presence of amino acid/ peptide compounds on the surface of silver nanoparticles produced by S. albidoflavus. Synthesized nanoparticles revealed a mean negative zeta potential and electrophoretic mobility of -8.5 mV and -0.000066 cm2/Vs, respectively. The nanoparticles produced were proteinaceous compounds as capping agents with -8.5 mV zeta potential and revealed antimicrobial activity against both Gram-negative and -positive bacterial strains. Owing to their small size, these particles have greater impact on industrial application spectra.