Stem Cells for the Treatment of Urinary Incontinence

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Abstract

Stress urinary incontinence (SUI) is highly prevalent. As of now, there is no minimally invasive long-term treatment available. Adult stem cells are nonimmunogenic and have the ability to self-renew and to differentiate into multiple cell types. Over the past decade, in vivo studies have described periurethral injections of adult-derived stem cells for the treatment of SUI. The ultimate goal has been to achieve a permanent cure for SUI by restoration of the intrinsic and extrinsic urethral sphincter and the surrounding connective tissue, including peripheral nerves and blood vessels. For this purpose, future studies need to focus on delivery systems, cell survival, and functional improvement of the urethral closure mechanism, including improvement of innervation and vascularization.

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Most cited references 48

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A new look at the origin, function, and "stem-cell" status of muscle satellite cells.

Patrick Seale, Michael A Rudnicki (2000)

Muscle satellite cells have long been considered a distinct myogenic lineage responsible for postnatal growth, repair, and maintenance of skeletal muscle. Recent studies in mice, however, have revealed the potential for highly purified hematopoietic stem cells from bone marrow to participate in muscle regeneration. Perhaps more significantly, a population of putative stem cells isolated directly from skeletal muscle efficiently reconstitutes the hematopoietic compartment and participates in muscle regeneration following intravenous injection in mice. The plasticity of muscle stem cells has raised important questions regarding the relationship between the muscle-derived stem cells and the skeletal muscle satellite cells. Furthermore, the ability of hematopoietic cells to undergo myogenesis has prompted new investigations into the embryonic origin of satellite cells. Recent developmental studies suggest that a population of satellite cells is derived from progenitors in the embryonic vasculature. Taken together, these studies provide the first evidence that pluripotential stem cells are present within adult skeletal muscle. Tissue-specific stem cells, including satellite cells, may share a common embryonic origin and possess the capacity to activate diverse genetic programs in response to environmental stimuli. Manipulation of such tissue-specific stem cells may eventually revolutionize therapies for degenerative diseases, including muscular dystrophy. Copyright 2000 Academic Press.

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Prevalence of urinary incontinence in men, women, and children--current evidence: findings of the Fourth International Consultation on Incontinence.

Brian S Buckley, Marie Carmela M Lapitan (2010)

To summarize existing evidence relating to the prevalence and risk factors of urinary incontinence in order to provide a concise reference source for clinicians, health researchers, and service planners. For the Fourth International Consultation on Incontinence (4th ICI) world experts identified, collated, and reviewed the best available evidence. Estimates of prevalence from different studies are presented as ranges. Most studies report some degree of urinary incontinence (UI) in 25-45% of women; 7-37% of women aged 20-39 report some UI; "daily UI" is reported by 9% to 39% of women over 60. Pregnancy, childbirth, diabetes and increased body mass index are associated with an increased risk of UI. Prevalence of UI in men approximately half that in women: UI is seen in 11-34% of older men, with 2-11% reporting daily UI. Surgery for prostate disease is associated with an increased risk. Some 10% of children aged seven, 3% of 11-12 years olds and 1% of 16-17 year olds are not dry at night. UI is clearly common, but accurate prevalence data have proven difficult to establish because of heterogeneity between studies in terms of methodologies, definitions of UI and populations considered. Future research should use standardized, validated and more readily comparable methods. Copyright 2010 Elsevier Inc. All rights reserved.

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1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence.

Derek S. Steele, Maria Carr, A Chancellor … (2008)

We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived stem cell injections. Mean and median follow-up in this group was 16.5 and 17 months (range 3-24 months). Improvement in SUI was seen in five of eight women, with one achieving total continence. Onset of improvement was between 3 and 8 months after injection. Cure or improvement continued at a median of 10 months. No serious adverse events were reported.

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Author and article information

Contributors

: LRodriguez@mednet.ucla.edu

Journal

Journal ID (nlm-ta): Curr Urol Rep

Title: Current Urology Reports

Publisher: Current Science Inc. (New York )

ISSN (Print): 1527-2737

ISSN (Electronic): 1534-6285

Publication date (Electronic): 27 November 2010

Publication date PMC-release: 27 November 2010

Publication date (Print): February 2011

Volume: 12

Issue: 1

Pages: 41-46

Affiliations

UCLA School of Medicine, 200 Medical Plaza, Suite 240, Los Angeles, CA 90095 USA

Article

Publisher ID: 155

DOI: 10.1007/s11934-010-0155-z

PMC ID: 3021255

PubMed ID: 21113694

SO-VID: c8a67682-e465-45a7-8036-d901798ab08e

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ScienceOpen disciplines: Urology

Keywords: periurethral injection,adipose-derived stem cells,bone marrow-derived stem cells,muscular-derived stem cells,adult stem cell therapy,mesenchymal-derived stem cells,stress urinary incontinence

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ScienceOpen disciplines: Urology

Keywords: periurethral injection, adipose-derived stem cells, bone marrow-derived stem cells, muscular-derived stem cells, adult stem cell therapy, mesenchymal-derived stem cells, stress urinary incontinence

Stem Cells for the Treatment of Urinary Incontinence

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Abstract

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Stress signalling in stem cells

Most cited references 48

A new look at the origin, function, and "stem-cell" status of muscle satellite cells.

Prevalence of urinary incontinence in men, women, and children--current evidence: findings of the Fourth International Consultation on Incontinence.

1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence.

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