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      Current limitations to identify covid-19 using artificial intelligence with chest x-ray imaging (part ii). The shortcut learning problem

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          Abstract

          Since the outbreak of the COVID-19 pandemic, computer vision researchers have been working on automatic identification of this disease using radiological images. The results achieved by automatic classification methods far exceed those of human specialists, with sensitivity as high as 100% being reported. However, prestigious radiology societies have stated that the use of this type of imaging alone is not recommended as a diagnostic method. According to some experts the patterns presented in these images are unspecific and subtle, overlapping with other viral pneumonias. This report seeks to evaluate the analysis the robustness and generalizability of different approaches using artificial intelligence, deep learning and computer vision to identify COVID-19 using chest X-rays images. We also seek to alert researchers and reviewers to the issue of “shortcut learning”. Recommendations are presented to identify whether COVID-19 automatic classification models are being affected by shortcut learning. Firstly, papers using explainable artificial intelligence methods are reviewed. The results of applying external validation sets are evaluated to determine the generalizability of these methods. Finally, studies that apply traditional computer vision methods to perform the same task are considered. It is evident that using the whole chest X-Ray image or the bounding box of the lungs, the image regions that contribute most to the classification appear outside of the lung region, something that is not likely possible. In addition, although the investigations that evaluated their models on data sets external to the training set, the effectiveness of these models decreased significantly, it may provide a more realistic representation as how the model will perform in the clinic. The results indicate that, so far, the existing models often involve shortcut learning, which makes their use less appropriate in the clinical setting.

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          Most cited references43

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          Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

          Highlights • Emergence of 2019 novel coronavirus (2019-nCoV) in China has caused a large global outbreak and major public health issue. • At 9 February 2020, data from the WHO has shown >37 000 confirmed cases in 28 countries (>99% of cases detected in China). • 2019-nCoV is spread by human-to-human transmission via droplets or direct contact. • Infection estimated to have an incubation period of 2–14 days and a basic reproduction number of 2.24–3.58. • Controlling infection to prevent spread of the 2019-nCoV is the primary intervention being used.
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            Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases

            Background Chest CT is used for diagnosis of 2019 novel coronavirus disease (COVID-19), as an important complement to the reverse-transcription polymerase chain reaction (RT-PCR) tests. Purpose To investigate the diagnostic value and consistency of chest CT as compared with comparison to RT-PCR assay in COVID-19. Methods From January 6 to February 6, 2020, 1014 patients in Wuhan, China who underwent both chest CT and RT-PCR tests were included. With RT-PCR as reference standard, the performance of chest CT in diagnosing COVID-19 was assessed. Besides, for patients with multiple RT-PCR assays, the dynamic conversion of RT-PCR results (negative to positive, positive to negative, respectively) was analyzed as compared with serial chest CT scans for those with time-interval of 4 days or more. Results Of 1014 patients, 59% (601/1014) had positive RT-PCR results, and 88% (888/1014) had positive chest CT scans. The sensitivity of chest CT in suggesting COVID-19 was 97% (95%CI, 95-98%, 580/601 patients) based on positive RT-PCR results. In patients with negative RT-PCR results, 75% (308/413) had positive chest CT findings; of 308, 48% were considered as highly likely cases, with 33% as probable cases. By analysis of serial RT-PCR assays and CT scans, the mean interval time between the initial negative to positive RT-PCR results was 5.1 ± 1.5 days; the initial positive to subsequent negative RT-PCR result was 6.9 ± 2.3 days). 60% to 93% of cases had initial positive CT consistent with COVID-19 prior (or parallel) to the initial positive RT-PCR results. 42% (24/57) cases showed improvement in follow-up chest CT scans before the RT-PCR results turning negative. Conclusion Chest CT has a high sensitivity for diagnosis of COVID-19. Chest CT may be considered as a primary tool for the current COVID-19 detection in epidemic areas. A translation of this abstract in Farsi is available in the supplement. - ترجمه چکیده این مقاله به فارسی، در ضمیمه موجود است.
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              Distinctive Image Features from Scale-Invariant Keypoints

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                Author and article information

                Contributors
                josedaniellc@uclv.cu
                rorozco@uclv.edu.cu
                jportal@uclv.cu
                lovelle@infomed.sld.cu
                mperez@uclv.edu.cu
                Journal
                Health Technol (Berl)
                Health Technol (Berl)
                Health and Technology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                2190-7188
                2190-7196
                10 October 2021
                : 1-15
                Affiliations
                [1 ]GRID grid.411059.8, Centro de Investigaciones de La Informática, Facultad de Matemática, Física y Computación , , Universidad Central “Marta Abreu” de Las Villas, ; Villa Clara, Santa Clara, Cuba
                [2 ]GRID grid.411059.8, Departamento de Control Automático, Facultad de Ingeniería Eléctrica, , Universidad Central “Marta Abreu” de Las Villas, ; Villa Clara, Santa Clara, Cuba
                [3 ]Departamento de Imagenología, Hospital Comandante Manuel Fajardo Rivero, Villa Clara, Santa Clara, Cuba
                Author information
                http://orcid.org/0000-0003-2137-0361
                http://orcid.org/0000-0002-6240-1569
                http://orcid.org/0000-0003-1360-4930
                http://orcid.org/0000-0003-3944-3514
                http://orcid.org/0000-0002-3706-9154
                Article
                609
                10.1007/s12553-021-00609-8
                8502237
                c9880041-bb81-47c0-8afd-69dd22b9432e
                © IUPESM and Springer-Verlag GmbH Germany, part of Springer Nature 2021

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 28 July 2021
                : 5 October 2021
                Categories
                Review Paper

                covid-19,chest x-rays,artificial intelligence,deep learning

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