Ca2+-CaM Dependent Inactivation of RyR2 Underlies Ca2+ Alternans in Intact Heart.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Ca2+ alternans plays an essential role in cardiac alternans that can lead to ventricular fibrillation, but the mechanism underlying Ca2+ alternans remains undefined. Increasing evidence suggests that Ca2+ alternans results from alternations in the inactivation of cardiac RyR2 (ryanodine receptor 2). However, what inactivates RyR2 and how RyR2 inactivation leads to Ca2+ alternans are unknown.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Circ Res

Title: Circulation research

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Feb 19 2021

Volume: 128

Issue: 4

Affiliations

[1 ] Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (J.W., J.Y., D.B., W.G., X.Z., B.S., R.W., J.P.E., S.R.W.C.).

[2 ] Department of Automatic Control, Universitat Politècnica de Catalunya, Barcelona, Spain (A.V., R.B.).

[3 ] Institut de Recerca Sant Joan de Déu (IRSJD), Barcelona, Spain (R.B.).

[4 ] Biomedical Research Institute Barcelona IIBB-CSIC, CIBERCV and IIB Sant Pau, Hospital de Sant Pau, Barcelona, Spain (L.H.-M.).

[5 ] Department of Physics, Universitat Politècnica de Catalunya, Barcelona, Spain (E.A.-L., B.E.).

Article

DOI: 10.1161/CIRCRESAHA.120.318429

PubMed ID: 33375811

SO-VID: c9d3bb4c-8d95-4467-84a0-1520723d8e44

History

Keywords: calmodulin,heart,ryanodine,sarcoplasmic reticulum,mutation

Data availability:

Keywords: calmodulin, heart, ryanodine, sarcoplasmic reticulum, mutation

Comments

Comment on this article

scite_

Cited by 7

See all cited by