Distal ileum resection totally suppresses the late pancreatic postprandial hypersecretion in conscious dogs

Abstract

Exocrine pancreatic secretion and serum levels of secretin, vasoactive intestinal peptide (VIP) and gastrin within postprandial 12 hours have been studied in dogs that have undergone a partial ileum resection (last 25 cm) 4 weeks before. In these conditions the following effects were observed: 1) the flow of pancreatic juice secreted after the food intake (1-4h period) was strictly similar to the flow described in intact dogs which did not suffer that surgical manipulation but it came back to its basal value more rapidly; 2) there were no effects regarding the postprandial hormonal pattern; 3) the late pancreatic hypersecretion period that is usually observed in intact dogs within the postprandial 8-12 h period, completely disappeared. These results allow to conclude that the mechanisms inducing the late hypersecretion process that usually takes place within the postprandial 8-12 h in dogs are generated in the distal ileum.