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      The Evaluation of Ureteroscopy and Pneumatic Lithotripsy Results in Pregnant Women With Urethral Calculi

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          Abstract

          Background

          Urinary stone incidence in pregnancy has been reported in a wide range, from 1 in 200 to 1 in 2000 cases.

          Objectives

          The aim of this study was to investigate the efficacy and safety of ureteroscopic treatment and its results and complications for pregnant women with urinary stones.

          Patients and Methods

          From 2003 till 2011, 113 pregnant patients with symptomatic urolithiasis were admitted to the urology emergency clinic at Imam Reza hospital. All patients were initially treated conservatively, resulting in spontaneous passage of the calculi in 69 patients. Forty-four patients with symptomatic urolithiasis were included in the study. Post-operative follow ups, including maternal and fetal health was performed by a gynecologist consult fetal heart rate assessment and urine analysis and culture and renal and urethral ultrasonography.

          Results

          The mean age of the patients was 23 years ± 2 (19-34) and the mean gestational age was 24 ± 3 weeks. The overall and pneumatic lithotripsy success rate was 100%. All patients from the interventional group delivered at term with no fetal or maternal complications. There was no morbidity during and after the operation.

          Conclusions

          In conditions, medical management of urinary stones and consequent renal colic in pregnant women cannot improve patients’ symptoms, choosing of a surgical method like setting of a DJ catheter or URS and pneumatic lithotripsy can be a safe and effective way for the health of both the mother and fetus. Of course, more research is needed to establish this approach as the standard method in pregnancy urinary stones.

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          Most cited references28

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          Hydronephrosis during pregnancy: a literature survey.

          The occurrence of hydronephrosis and hydroureters during pregnancy has been termed physiological, inasmuch as it is seen in more than 80%, most frequently and most pronounced in primigravida. The dilatation develops during the second trimester, and becomes more prominent on the right side, is only seen above the linea terminalis and disappears within a few weeks after birth. The condition is not seen in women whose ureters do not cross the pelvic brim. The extent of the dilatation can be reduced by placing the woman on the side least affected or in the knee-elbow position. After a survey of the literature, the conclusion is reached that today there is every probability that hydronephrosis during pregnancy develops as a result of compression of the ureters between the pregnant uterus and the linea terminalis. It has not been demonstrated that the change in hormonal balance during pregnancy is of importance. The clinical significance of hydronephrosis lies in the association between ureteral obstruction and the high frequency of ascending urinary tract infection during pregnancy and in the understanding of the importance--in the treatment of infection--of improving drainage by means of a change in position. Isotope renographic studies seem to show a possible relationship between bilateral ureteral obstruction and the development of pre-eclampsia. Similarly, it appears that acute hydronephrosis or worsening of an existing hydronephrosis has been somewhat overlooked as a possible cause of uncertain abdominal pain during pregnancy. These conditions should be examined by means of ultrasonography, and an attempt at treatment by a change in position should be made. In cases of continued pain or affected renal function, treatment should consist of the insertion of a ureteral catheter.
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            The safety of ureteroscopy during pregnancy: a systematic review and meta-analysis.

            We performed a literature review and analysis to compare the safety of ureteroscopic stone removal during pregnancy with findings from a set of contemporary studies of that procedure in nonpregnant patients. A systematic review of MEDLINE(R) and EMBASE(R) was done to identify all reports of ureteroscopic stone removal in pregnant women. Complications were stratified according to modified Clavien criteria. We then reviewed a contemporary, multi-national meta-analysis of ureteroscopic stone removal (American Urological Association/European Association of Urology 2007 Guideline for the Management of Ureteral Calculi) to define the complication rate in a series of nonpregnant patients. Complication rates in the 2 reviews were compared using Fisher's exact test. A total of 14 reports of ureteroscopic stone removal in pregnant women were identified, representing 108 patients. Nine complications were noted. By Clavien criteria 2 complications were level 1, 6 were level 2 and 1 was level 3. When compared to the multinational meta-analysis of ureteroscopy in nonpregnant women, there was no significant difference in the ureteral injury and urinary tract infection complication rates (p = 0.191 and 0.597, respectively). Our analysis shows that the safety of ureteroscopic stone removal in pregnant patients is not significantly different from the safety of that procedure in nonpregnant patients and in each cohort the complication rate is low. Therefore, ureteroscopic stone removal may reasonably be considered appropriate first line therapy in pregnant patients with stone disease.
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              Shock wave lithotripsy or ureteroscopy for the management of proximal ureteral calculi: an old discussion revisited.

              The goal of treating ureteral calculi is to achieve complete stone clearance with minimal patient morbidity. Shock wave lithotripsy and ureteroscopy have become standards of care for ureteral calculi. However, the optimal choice of treatment depends on various factors, including stone size, composition and location, clinical patient factors, equipment availability and surgeon capability. Indications for and outcomes data on shock wave lithotripsy and ureteroscopy for proximal ureteral calculi were reviewed to provide recommendations on the optimal treatment choice for managing symptomatic ureteral calculi. A systematic review was performed based on an English literature search using the MEDLINE database between 1997 and 2005. The key words used were proximal ureteral calculi, ureteroscopy and shock wave lithotripsy. A total of 87 articles were identified, of which 33 were selected for inclusion. Shock wave lithotripsy and ureteroscopy provided an excellent stone-free rate (86% to 90%) for stones less than 10 mm, whereas for larger stones ureteroscopy achieved better outcomes vs shock wave lithotripsy (67% vs 73%). Ureteroscopy was preferred over shock wave lithotripsy in patients with pregnancy or bleeding diathesis. Ureteroscopy provides optimal stone clearance in patients with proximal ureteral calculi more than 10 mm. It is also recommended in patients with contraindications for shock wave lithotripsy. In patients with smaller stones (less than 10 mm) shock wave lithotripsy may be considered a reasonable alternative with outcomes similar to those of ureteroscopy.
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                Author and article information

                Journal
                Nephrourol Mon
                Nephrourol Mon
                10.5812/numonthly
                Kowsar
                Nephro-urology Monthly
                Kowsar
                2251-7006
                2251-7014
                12 August 2013
                September 2013
                : 5
                : 4
                : 874-878
                Affiliations
                [1 ]Department of Urology, Imam Reza Academic Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran
                [2 ]Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
                Author notes
                [* ]Corresponding author: Hamid Reza Rahimi, Student Research Committee, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran. Tel: +98-5118764100, Fax: +98-5118002287, E-mail: Rahimihr891@ 123456mums.ac.ir .
                Article
                10.5812/numonthly.10726
                3842557
                cad9b9ea-e336-473c-9dde-2176d6d6030c
                Copyright © 2013, Nephrology and Urology Research Center

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 13 February 2013
                : 23 March 2013
                : 08 May 2013
                Categories
                Research Article

                urinary calculi,urolithiasis,lithotripsy
                urinary calculi, urolithiasis, lithotripsy

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