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      Intraoperative Hyperkalemia Due to Surgical Manipulation of a Thymoma

      case-report
      1 , , 1 , 1
      ,
      Cureus
      Cureus
      hyperkalemia, thymoma, anterior mediastinal mass, tumor lysis syndrome

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          Abstract

          Episodic hyperkalemia has not been described during resection of a primary thymoma tumor. We present a case of significant intraoperative hyperkalemia during a technically challenging resection of a type B-1 thymoma. The hyperkalemia, presumed to be secondary to considerable tumor manipulation, was successfully controlled with calcium, bicarbonate, and insulin with dextrose. Although strict criteria for tumor lysis syndrome were not met, this possibility was included in the differential diagnosis. This case highlights the importance of close intraoperative electrolyte monitoring and prompt treatment of hyperkalemia during challenging thymoma resection.

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          Most cited references14

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          Thymoma and thymic carcinomas.

          Thymomas (Ts) and thymic carcinomas (TCs) are rare tumours of the mediastinum with an incidence rate of 1.7/million per year in Europe. Histological classification is based on rate of non-malignant-appearing thymic epithelial cells and proportions of lymphocytes (A, AB, B1, B2, B3, and C), while staging system concerns localisation of the involved areas. Surgery is the mainstay of treatment with a 10-year survival of 80%, 78%, 75%, and 42% for stages I, II, III and IV, respectively, with an R0 resection. Radiotherapy has a role in selected cases (stage III patients or R1-2 residual) and platinum-based chemotherapy remains the standard of care for patients with advanced disease. A multimodality approach would be advisable when surgery is not recommended. Since molecular aberrations are poorly understood and few responses are reported, targeted therapies are yet being studied. In this review, we describe key aspects of clinical management for Ts and TCs.
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            Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology.

            Masses in the anterior mediastinum can be neoplasms (eg, thymomas, thymic carcinomas, or lung metastases) or non-neoplastic conditions (eg, intrathoracic goiter). Thymomas are the most common primary tumor in the anterior mediastinum, although they are rare. Thymic carcinomas are very rare. Thymomas and thymic carcinomas originate in the thymus. Although thymomas can spread locally, they are much less invasive than thymic carcinomas. Patients with thymomas have 5-year survival rates of approximately 78%. However, 5-year survival rates for thymic carcinomas are only approximately 40%. These guidelines outline the evaluation, treatment, and management of these mediastinal tumors.
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              Diagnosis and treatment of hyperkalemia

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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                8 March 2021
                March 2021
                : 13
                : 3
                : e13758
                Affiliations
                [1 ] Anesthesiology, University of Florida, Gainesville, USA
                Author notes
                Article
                10.7759/cureus.13758
                8022680
                cadf5631-fb47-4ddf-b040-0644b96a7f4a
                Copyright © 2021, Mallett et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 7 March 2021
                Categories
                Anesthesiology
                General Surgery

                hyperkalemia,thymoma,anterior mediastinal mass,tumor lysis syndrome

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