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      Rethinking Neandertals

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      Annual Review of Anthropology
      Annual Reviews

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          Abstract

          In this article, I first provide an overview of the Neandertals by recounting their initial discovery and subsequent interpretation by scientists and by discussing our current understanding of the temporal and geographic span of these hominins and their taxonomic affiliation. I then explore what progress we have made in our understanding of Neandertal lifeways and capabilities over the past decade in light of new technologies and changing perspectives. In the process, I consider whether these advances in knowledge qualify as so-called Black Swans, a term used in economics to describe events that are rare and unpredictable and have wide-ranging consequences, in this case for the field of paleoanthropology. Building on this discussion, I look at ongoing debates and focus on Neandertal extinction as a case study. By way of discussion and conclusion, I take a detailed look at why Neandertals continue to engender great interest, and indeed emotion, among scientists and the general public alike.

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          Most cited references143

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          A draft sequence of the Neandertal genome.

          Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development. We show that Neandertals shared more genetic variants with present-day humans in Eurasia than with present-day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
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            Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins.

            A unique assemblage of 28 hominin individuals, found in Sima de los Huesos in the Sierra de Atapuerca in Spain, has recently been dated to approximately 430,000 years ago. An interesting question is how these Middle Pleistocene hominins were related to those who lived in the Late Pleistocene epoch, in particular to Neanderthals in western Eurasia and to Denisovans, a sister group of Neanderthals so far known only from southern Siberia. While the Sima de los Huesos hominins share some derived morphological features with Neanderthals, the mitochondrial genome retrieved from one individual from Sima de los Huesos is more closely related to the mitochondrial DNA of Denisovans than to that of Neanderthals. However, since the mitochondrial DNA does not reveal the full picture of relationships among populations, we have investigated DNA preservation in several individuals found at Sima de los Huesos. Here we recover nuclear DNA sequences from two specimens, which show that the Sima de los Huesos hominins were related to Neanderthals rather than to Denisovans, indicating that the population divergence between Neanderthals and Denisovans predates 430,000 years ago. A mitochondrial DNA recovered from one of the specimens shares the previously described relationship to Denisovan mitochondrial DNAs, suggesting, among other possibilities, that the mitochondrial DNA gene pool of Neanderthals turned over later in their history.
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              Analysis of one million base pairs of Neanderthal DNA.

              Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA. Direct high-throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort.
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                Author and article information

                Journal
                Annual Review of Anthropology
                Annu. Rev. Anthropol.
                Annual Reviews
                0084-6570
                1545-4290
                October 23 2023
                October 23 2023
                : 52
                : 1
                : 151-170
                Affiliations
                [1 ]Department of Anthropology, University of Victoria, Victoria, British Columbia, Canada;
                Article
                10.1146/annurev-anthro-052621-024752
                cb731050-5683-4677-b4df-abd9ce534d3b
                © 2023

                http://creativecommons.org/licenses/by/4.0/

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