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      Fucoidans: Downstream Processes and Recent Applications

      review-article
      1 , 2 , 1 , *
      Marine Drugs
      MDPI
      fucoidans, extraction, brown algae, production, bioactivities

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          Abstract

          Fucoidans are multifunctional marine macromolecules that are subjected to numerous and various downstream processes during their production. These processes were considered the most important abiotic factors affecting fucoidan chemical skeletons, quality, physicochemical properties, biological properties and industrial applications. Since a universal protocol for fucoidans production has not been established yet, all the currently used processes were presented and justified. The current article complements our previous articles in the fucoidans field, provides an updated overview regarding the different downstream processes, including pre-treatment, extraction, purification and enzymatic modification processes, and shows the recent non-traditional applications of fucoidans in relation to their characters.

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          Most cited references162

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          Can Seaweed Farming Play a Role in Climate Change Mitigation and Adaptation?

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            Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

            There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of brown seaweed, has anti-cancer activity against various cancer types by targeting key apoptotic molecules. It also has beneficial effects as it can protect against toxicity associated with chemotherapeutic agents and radiation. Thus the synergistic effect of fucoidan with current anti-cancer agents is of considerable interest. This review discusses the mechanisms by which fucoidan retards tumor development, eradicates tumor cells and synergizes with anti-cancer chemotherapeutic agents. Challenges to the development of fucoidan as an anti-cancer agent will also be discussed.
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              Ascophyllum nodosum -Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management

              Abiotic and biotic stresses limit the growth and productivity of plants. In the current global scenario, in order to meet the requirements of the ever-increasing world population, chemical pesticides and synthetic fertilizers are used to boost agricultural production. These harmful chemicals pose a serious threat to the health of humans, animals, plants, and the entire biosphere. To minimize the agricultural chemical footprint, extracts of Ascophyllum nodosum (ANE) have been explored for their ability to improve plant growth and agricultural productivity. The scientific literature reviewed in this article attempts to explain how certain bioactive compounds present in extracts aid to improve plant tolerances to abiotic and/or biotic stresses, plant growth promotion, and their effects on root/microbe interactions. These reports have highlighted the use of various seaweed extracts in improving nutrient use efficiency in treated plants. These studies include investigations of physiological, biochemical, and molecular mechanisms as evidenced using model plants. However, the various modes of action of A. nodosum extracts have not been previously reviewed. The information presented in this review depicts the multiple, beneficial effects of A. nodosum-based biostimulant extracts on plant growth and their defense responses and suggests new opportunities for further applications for marked benefits in production and quality in the agriculture and horticultural sectors.
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                Author and article information

                Journal
                Mar Drugs
                Mar Drugs
                marinedrugs
                Marine Drugs
                MDPI
                1660-3397
                18 March 2020
                March 2020
                : 18
                : 3
                : 170
                Affiliations
                [1 ]Institute of Bioprocess Engineering, Technical University of Kaiserslautern, Gottlieb-Daimler-Straße 49, 67663 Kaiserslautern, Germany; ahmed.zayed1@ 123456pharm.tanta.edu.eg
                [2 ]Department of Pharmacognosy, Tanta University, College of Pharmacy, El Guish Street, Tanta 31527, Egypt
                Author notes
                [* ]Correspondence: ulber@ 123456mv.uni-kl.de ; Tel.: +49-0631-205-4043; Fax: +49-6312-05-4312
                Author information
                https://orcid.org/0000-0001-5747-6972
                Article
                marinedrugs-18-00170
                10.3390/md18030170
                7142712
                32197549
                cc1c7fe3-f505-468c-9b11-73a030af6e38
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 06 February 2020
                : 15 March 2020
                Categories
                Review

                Pharmacology & Pharmaceutical medicine
                fucoidans,extraction,brown algae,production,bioactivities
                Pharmacology & Pharmaceutical medicine
                fucoidans, extraction, brown algae, production, bioactivities

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