7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Acute rheumatic fever and its consequences: a persistent threat to developing nations in the 21st century.

      1 , , ,

      Autoimmunity reviews

      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Acute rheumatic fever (ARF) is an autoimmune, multi-system response secondary to molecular mimicry following Lancefield group A streptococcus (GAS) pharyngitis; it is now most commonly found in the pediatric populations of developing nations. The major source of morbidity and mortality of ARF stems from rheumatic heart disease (RHD), although the cardinal symptoms of the disease also include polyarthritis, Sydenham's chorea, subcutaneous nodules, and erythema marginatum. Therapy is aimed towards treating the initial GAS infection, using anti-inflammatory medications for acute symptoms and surgery to correct RHD. Secondary prevention is crucial, given the high risk of recurrence, and includes long-term antibiotic prophylaxis. However, vaccination towards GAS may soon be on the horizon, which may assist in both decreasing the risk of initial infection in naïve patients and helping to lower the risk of recurrence.

          Related collections

          Author and article information

          Journal
          Autoimmun Rev
          Autoimmunity reviews
          Elsevier BV
          1873-0183
          1568-9972
          Dec 2009
          : 9
          : 2
          Affiliations
          [1 ] Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Suite 6510, Davis, CA 95616, USA.
          Article
          S1568-9972(09)00089-5
          10.1016/j.autrev.2009.04.002
          19386288
          cc8460b9-a7fc-4e46-ae84-bd57f75291a4

          Comments

          Comment on this article