TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms.

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Abstract

Previously, the family of S100A proteins has been found to be associated with inflammation and myelopoiesis and to be able to induce or support myeloproliferation during chronic inflammation. Here, we studied the inflammatory myeloid-related proteins S100A4, S100A8, S100A9 and S100A12 in myeloproliferative neoplasms (MPNs) in order to assess the involvement of chronic inflammation in the pathogenesis of MPN.

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Journal

Journal ID (iso-abbrev): Cell Oncol (Dordr)

Title: Cellular oncology (Dordrecht)

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 2211-3436

ISSN (Print): 2211-3428

Publication date (Electronic): Oct 2018

Volume: 41

Issue: 5

Affiliations

[1 ] Department of Molecular Oncology, Institute for Medical Research, University of Belgrade, Dr. Subotica 4, Belgrade, 11129, Serbia.

[2 ] Clinic for Endocrinology, Diabetes and Metabolic Diseases, Genetic laboratory, Clinical Center of Serbia, Belgrade, Serbia.

[3 ] Clinic of Hematology, Clinical Center of Serbia, Belgrade, Serbia.

[4 ] Medical Faculty, University of Belgrade, Belgrade, Serbia.

[5 ] Département d'Hématologie, Institut de Biologie et Pathologie, CHU Grenoble, Grenoble, France.

[6 ] Department of Molecular Oncology, Institute for Medical Research, University of Belgrade, Dr. Subotica 4, Belgrade, 11129, Serbia. vl@imi.bg.ac.rs.

Article

Publisher Item ID: 10.1007/s13402-018-0392-6

DOI: 10.1007/s13402-018-0392-6

PubMed ID: 29946821

SO-VID: cc939ea0-edbd-461c-8704-e31f00cbf748

History

Keywords: S100A proteins,ERK1/2 signaling,AKT signaling,Inflammation,Myeloproliferative neoplasm

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Keywords: S100A proteins, ERK1/2 signaling, AKT signaling, Inflammation, Myeloproliferative neoplasm

TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms.

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