Associations between waist circumference, central obesity, and the presence of non-valvular atrial fibrillation patients with heart failure

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Reportedly, there is a clear correlation between waist circumference (WC) and atrial fibrillation (AF). However, there is no specific discussion about the relationship between WC and non-valvular AF (NVAF) patients with heart failure. Our main purpose was to study the relationship between WC, central obesity (CO), and NVAF patients with heart failure.

Methods

This is a retrospective cohort study. A total of 3,435 patients with NVAF in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2017 were enrolled. The targeted independent variable and the dependent variable were WC and CO and the presence of NVAF with heart failure, respectively. Univariate, multiple regression, and subgroup analyses were used to analyze their relationship. We used the receiver operating characteristic (ROC) curve to choose the better predictor of NVAF with heart failure between WC and CO and calculated the proposed cut-off value of WC in males and female separately.

Results

The identified risk factors of NVAF with heart failure were sex, height, WC, CO, body mass index (BMI), fasting blood glucose (FBG), homocysteine (HCY), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), hypertension, diabetes mellitus (DM), stroke, vascular disease, and plaque. Then, a binary logistic regression model indicated that the occurrence of NVAF patients with heart failure increased 10% with WC increasing 1 cm and had a 2.8-fold increased risk with CO compared to those without. The predictive value [area under the ROC curve (AUC)], specificity, sensitivity, and accuracy of WC for the disease risk of NVAF with heart failure were higher than those of CO. The proposed cut-off value of WC was 91.85 cm for males and 93.15 cm for females. The diagnostic value of WC for NVAF with heart failure was higher for females than it was for males.

Conclusions

Our research found that WC is related to the presence of heart failure in the patients with NYAF and can predict the presence of NVAF with heart failure. Our findings may help to improve the treatment and care strategies of NVAF individuals with abdominal obesity.

Related collections

Most cited references 27

Record: found
Abstract: found
Article: not found

Obesity and hypertension.

Gino Seravalle, Guido Grassi (2017)

Obesity and in particular the excessive visceral fat distribution is accompanied by several alterations at hormonal, inflammatory and endothelial level. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and on the other side to increase the cardiovascular morbidity. In these chapter we will examine the main mechanisms of obesity and obesity-related hypertension and in particular the role of sympathetic nervous system, the alterations of the renal function and at the microvascular level. We will also depict the role of insulin resistance as factor stimulating and potentiating the other mechanisms. The second part will be focalized on the major target organ damage linked with obesity and obesity-related hypertension. We will finally describe the management and treatment of obesity and the antihypertensive drug therapies more effective in hypertensive obeses.

0 comments Cited 205 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Waist circumference as a measure for indicating need for weight management.

M. Lean, T S Han, C Morrison (1995)

To test the hypothesis that a single measurement, waist circumference, might be used to identify people at health risk both from being overweight and from having a central fat distribution. A community derived random sample of men and women and a second, validation sample. North Glasgow. 904 men and 1014 women (first sample); 86 men and 202 women (validation sample). Waist circumference, body mass index, waist:hip ratio. Waist circumference > or = 94 cm for men and > or = 80 cm for women identified subjects with high body mass index (> or = 25 kg/m2) and those with lower body mass index but high waist:hip ratio (> or = 0.95 for men, > or = 0.80 women) with a sensitivity of > 96% and specificity > 97.5%. Waist circumference > or = 102 cm for men or > or = 88 cm for women identified subjects with body mass index > or = 30 and those with lower body mass index but high waist:hip ratio with a sensitivity of > 96% and specificity > 98%, with only about 2% of the sample being misclassified. Waist circumference could be used in health promotion programmes to identify individuals who should seek and be offered weight management. Men with waist circumference > or = 94 cm and women with waist circumference > or = 80 cm should gain no further weight; men with waist circumference > or = 102 cm and women with waist circumference > or = 88 cm should reduce their weight.

0 comments Cited 180 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Pathophysiology of Heart Failure.

Edit Tanai, Stefan Frantz (2015)

Heart failure is considered an epidemic disease in the modern world affecting approximately 1% to 2% of adult population. It presents a multifactorial, systemic disease, in which--after cardiac injury--structural, neurohumoral, cellular, and molecular mechanisms are activated and act as a network to maintain physiological functioning. These coordinated, complex processes lead to excessive volume overload, increased sympathetic activity, circulation redistribution, and result in different, parallel developing clinical signs and symptoms. These signs and symptoms sum up to an unspecific clinical picture; thus invasive and noninvasive diagnostic tools are used to get an accurate diagnosis and to specify the underlying cause. The most important, outcome determining factor in heart failure is its constant progression. Constant optimizing of pharmatherapeutical regimes, novel targets, and fine regulation of these processes try to keep these compensatory mechanisms in a physiological range. Beside pharmacological therapy, interventional and surgical therapy options give new chances in the management of heart failure. For the optimization and establishment of these and novel therapeutical approaches, complete and comprehensive understanding of the underlying mechanisms is essentially needed. Besides diagnosis and treatment, efforts should be made for better prevention in heart failure by treatment of risk factors, or identifying and following risk groups. This summary of the pathophysiology of heart failure tries to give a compact overview of basic mechanisms and of the novel unfolding, progressive theory of heart failure to contribute to a more comprehensive knowledge of the disease.

0 comments Cited 149 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): J Thorac Dis

Journal ID (iso-abbrev): J Thorac Dis

Journal ID (publisher-id): JTD

Title: Journal of Thoracic Disease

Publisher: AME Publishing Company

ISSN (Print): 2072-1439

ISSN (Electronic): 2077-6624

Publication date (Electronic): 27 March 2024

Publication date (Print): 29 March 2024

Volume: 16

Issue: 3

Pages: 2049-2059

Affiliations

[1 ]deptDepartment of Cardiology , The Affiliated Hospital of Guizhou Medical University , Guiyang, China;

[2 ]deptDepartment of Internal Medicine, School of Clinical Medicine , Guizhou Medical University , Guiyang, China;

[3 ]deptDepartment of Laboratory , Guiyang Public Health Clinical Center , Guiyang, China;

[4 ]deptCardiology Department , Hospital Universitario La Paz , Madrid, Spain;

[5 ]deptDepartment of Cardiothoracic Surgery , National Heart Centre Singapore , Singapore, Singapore;

[6 ]deptDepartment of Physiology and Biophysics , University of Washington , Seattle, WA, USA

Author notes

Contributions: (I) Conception and design: H Zhou, X Liu; (II) Administrative support: H Zhou; (III) Provision of study materials or patients: N Huang; (IV) Collection and assembly of data: B Wang, X Yang, B Wei, T Ren; (V) Data analysis and interpretation: B Wang, X Yang, B Wei, T Ren; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

[#]

These authors contributed equally to this work.

Correspondence to: Haiyan Zhou, PhD. Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyi No. 28 ^thStreet, Yunyan District, Guiyang 550000, China; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA. Email: hyzhou88@ 123456uw.edu ; Xingde Liu, MD. Department of Internal Medicine, School of Clinical Medicine, Guizhou Medical University, Dongqin No. 4 Street, Huaxi District, Guiyang 550000, China. Email: lxd@ 123456gmc.edu.cn .

Article

Publisher ID: jtd-16-03-2049

DOI: 10.21037/jtd-24-170

PMC ID: 11009574

SO-VID: cd0eb09c-bacf-4961-ac30-819a7772b5f3

License:

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

History

Date received : 29 January 2024

Date accepted : 18 March 2024

Funding

Funded by: the National Natural Science Foundation of China

Award ID: Nos. 82360990, 81904319

Funded by: China Postdoctoral Science Foundation

Award ID: No. 2022MD723769

Funded by: the Science and Technology Fund of Guizhou Provincial Health Department

Award ID: Nos. qiankehejichu-ZK[2022]zhongdian043, qiankehejichu-ZK[2022] yiban423

Funded by: the Health and Family Planning Commission of Guizhou Province

Award ID: Nos. gzwjkj2021-106, gzwjkj2020-1-083, gzwkj2023-525

Funded by: the Fund of Guiyang Science and Technology Department

Award ID: No. zhukehetong[2021]43-6

Funded by: the Fund of the Affiliated Hospital of Guizhou Medical University

Award ID: Nos. gyfybsky-2021-33, 2021-GNHCT-020, gyfyxkyc-2023-10, GYFYBSKY-2021-49

Associations between waist circumference, central obesity, and the presence of non-valvular atrial fibrillation patients with heart failure

Read this article at

Abstract

Background

Methods

Results

Conclusions

Related collections

University of Westminster Press

Most cited references 27

Obesity and hypertension.

Waist circumference as a measure for indicating need for weight management.

Pathophysiology of Heart Failure.

Author and article information

Journal

Affiliations

Author notes

Article

History

Funding

Categories

Comments

Comment on this article

Similar content 218

Most referenced authors 417