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      Patterns of Experimental Allergic Uveitis Induced by Rhodopsin and Retinal Rod Outer Segments

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          We have observed that both washed outer segments and purified rhodopsin produce primarily a posterior uveitis with little or no anterior segment inflammation if an effort is made to remove all contaminating soluble retinal antigen. The differences in the immunopathologic responses to rhodopsin compared to soluble retinal antigen may be explained by the solubility difference between these antigens. With the soluble retinal antigen there may be anterior segment inflammation and diffuse tissue necrosis. The allergic response to rhodopsin appears to be confined to the posterior segment with tissue necrosis in severe cases restricted to the anatomic distribution of rhodopsin in the outer retina.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 12
          : 3
          : 165-176
          Georgetown University Medical Center, Washington, D.C.; National Eye Institute National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md., and University of Louisville, Louisville, Ky.
          265073 Ophthalmic Res 1980;12:165–176
          © 1980 S. Karger AG, Basel

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          Pages: 12
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