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      The anti-inflammatory activity of a low molecular weight component derived from the milk of hyperimmunized cows

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          Origin of IgA-secreting plasma cells in the mammary gland

          Lymphoblasts from the mesenteric lymph nodes (MN) of mice home to the mammary glands of syngeneic recipients late in pregnancy and during lactation, and within hours of transfer most can be shown to contain IgA. Homing does not occur in virgins, in early pregnancy, or after weaning. Homing MN lymphoblasts are sensitive to antiserum to IgA plus complement, but not to other class-specific antisera. Thus, lymphoblasts in MN with the potential to home to the mammary gland are already committed to IgA synthesis and bear surface IgA before reaching their destination. These results explain observations, made by others, of specific IgA antibodies and IgA plasma cells in milk and colostrum after oral immunization. Under natural conditions it is likely that IgA precursor cells, after stimulation in the gut-associated lymphoid tissue by intestinal antigens, migrate to the mammary gland where they secrete antibodies which constitute an important defense mechanism of the newborn. In the absence of lactation, these cells probably form part of the normal traffic to the lamina propria of the small intestine.
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            Antibody-forming cells in human colostrum after oral immunisation.

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              Host resistance factors in human milk.

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                Author and article information

                Journal
                Agents and Actions
                Agents and Actions
                Springer Nature
                0065-4299
                1420-908X
                March 1991
                March 1991
                : 32
                : 3-4
                : 160-166
                Article
                10.1007/BF01980868
                © 1991
                Product

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