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      Cardiovascular Response to Vasopressin Vasopressor Antagonist Administration during Water Deprivation in the Rat

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          Abstract

          The cardiovascular effects of intracerebroventricular (i.c.v.) and intravenous (i.v.) injection of a selective vasopressin vasopressor antagonist, [1-(β-mercapto-β, β-cyclopentamethylenepropionic acid-2-(0-methyl)tyrosine]arginine vasopressin (TMe-AVP) were examined in conscious rats under basal conditions and following 48 h of water deprivation. Pressor responses to i.v. vasopressin (50 ng/kg) were not blunted by i.c.v. treatment with either vehicle or 0.5 µg/kg TMe-AVP. A dose of 5.0 µg/kg TMe-AVP (i.c.v.) did reduce the pressor response to vasopressin, indicating peripheral leakage of the antagonist. Water deprivation for 48 h increased plasma vasopressin concentrations from 0.7 ± 0.1 to 2.8 ± 0.1 µU/ml and increased blood pressure from 112 ± 2 to 123 ± 1 mm Hg. No effect of the vasopressin antagonist on blood pressure could be detected following either i.c.v. (0.5 µg/kg) or i.v. (5.0 µg/kg) treatment in water-deprived animals. However, a significant increase in heart rate was observed in water-deprived rats following i.v. injection of 5.0 µg/kg of TMe-AVP. Central vasopressin vasopressor receptor blockade appears to exert little effect on blood pressure either under basal conditions or during water deprivation. The data further delineate the relationship of plasma vasopressin concentrations to cardiovascular homeostasis.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1984
          1984
          28 March 2008
          : 38
          : 2
          : 139-144
          Affiliations
          Department of Physiology and Biophysics, University of Tennessee Center for the Health Sciences, Memphis, Tenn., USA
          Article
          123881 Neuroendocrinology 1984;38:139–144
          10.1159/000123881
          6546972
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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