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      Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma - review article

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          Abstract

          Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma, a malignancy that accounts for about 80% of deaths from skin cancer. Because the diagnosis of melanoma at an early stage is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers is essential, as well as the creation of recommended preventative measures that must be taken by these patients.

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          Final version of 2009 AJCC melanoma staging and classification.

          Charles M. Balch, Jeffrey Gershenwald, Seng-jaw Soong … (2010)
          To revise the staging system for cutaneous melanoma on the basis of data from an expanded American Joint Committee on Cancer (AJCC) Melanoma Staging Database. The melanoma staging recommendations were made on the basis of a multivariate analysis of 30,946 patients with stages I, II, and III melanoma and 7,972 patients with stage IV melanoma to revise and clarify TNM classifications and stage grouping criteria. Findings and new definitions include the following: (1) in patients with localized melanoma, tumor thickness, mitotic rate (histologically defined as mitoses/mm(2)), and ulceration were the most dominant prognostic factors. (2) Mitotic rate replaces level of invasion as a primary criterion for defining T1b melanomas. (3) Among the 3,307 patients with regional metastases, components that defined the N category were the number of metastatic nodes, tumor burden, and ulceration of the primary melanoma. (4) For staging purposes, all patients with microscopic nodal metastases, regardless of extent of tumor burden, are classified as stage III. Micrometastases detected by immunohistochemistry are specifically included. (5) On the basis of a multivariate analysis of patients with distant metastases, the two dominant components in defining the M category continue to be the site of distant metastases (nonvisceral v lung v all other visceral metastatic sites) and an elevated serum lactate dehydrogenase level. Using an evidence-based approach, revisions to the AJCC melanoma staging system have been made that reflect our improved understanding of this disease. These revisions will be formally incorporated into the seventh edition (2009) of the AJCC Cancer Staging Manual and implemented by early 2010.
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            Melanoma.

            Arlo J. Miller, Martin C. Mihm (2006)
            Article 0 comments Cited 367 times – based on 0 reviews     Review now
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              Is Open Access

              Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi.

              Sara Gandini, Francesco Sera, Maria Sofia Cattaruzza … (2005)
              A systematic meta-analysis of observational studies of melanoma and one of the most important risk factors, the number of naevi, was conducted in order to clarify aspects of the aetiology of this disease. Following a systematic literature search, relative risks (RRs) were extracted from 46 studies published before September 2002. Dose-response random effects models were used to obtain pooled estimates. Sub-group analysis and meta-regression were carried out to explore sources of between-study variation and bias. Sensitivity analyses investigated the reliability of the results and any publication bias. Number of common naevi was confirmed an important risk factor with a substantially increased risk associated with the presence of 101-120 naevi compared with <15 (pooled Relative Risk (RR) = 6.89; 95% Confidential Interval (CI): 4.63, 10.25) as was the number of atypical naevi (RR = 6.36 95%; CI: 3.80, 10.33; for 5 versus 0). The type of study and source of cases and controls were two study characteristics that significantly influenced the estimates. Case-control studies, in particular when the hospital was the source for cases or controls, appeared to present much lower and more precise estimates than cohort studies.
              Article 0 comments Cited 173 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clinics (Sao Paulo)
                Title: Clinics
                Publisher: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
                ISSN (Print): 1807-5932
                ISSN (Electronic): 1980-5322
                Publication date (Print): March 2011
                Volume: 66
                Issue: 3
                Pages: 493-499
                Affiliations
                [I ]Oncology School Celestino Bourroul Hospital AC Camargo, Sã Paulo, SP, Brazil.
                [II ]Skin Oncology Department Hospital AC Camargo Sã Paulo, SP, Brazil.
                [III ]Pathology Department Hospital AC Camargo Sã Paulo, SP, Brazil.
                Author notes
                E-mail: bianca.sa@ 123456terra.com.br Tel.: 55 11 2189-5135
                Article
                Publisher ID: cln_66p493
                DOI: 10.1590/S1807-59322011000300023
                PMC ID: 3072014
                PubMed ID: 21552679
                SO-VID: d0c4f7bb-b743-4ced-88bf-861e127fed02
                Copyright © Copyright © 2011 Hospital das Clínicas da FMUSP
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 23 November 2010
                Date revision received : 24 November 2010
                Date accepted : 24 November 2010
                Page count
                Pages: 7
                Categories
                Subject: Review

                ScienceOpen disciplines: Medicine
                Keywords: early diagnosis,melanoma,dysplastic nevi,risk factors,dysplastic nevus syndrome
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: early diagnosis, melanoma, dysplastic nevi, risk factors, dysplastic nevus syndrome

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