Colorectal cancer (CRC) involves the abnormal expression of a set of genetic and epigenetic genes, which may be useful for predicting prognosis. The transcription factor homeobox C9 (HOXC9) is a member of the homeobox family and participates in diverse cellular metabolic processes. In the current study, the prognostic value of HOXC9 in CRC was evaluated by analyzing public data from The Cancer Genome Atlas.