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      Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors : A Randomized Clinical Trial

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          Abstract

          Although oral metronomic chemotherapy is often used in progressive pediatric solid malignant tumors, a literature review reveals that only small single-arm retrospective or phase 1 and 2 studies have been performed. Skepticism abounds because of the lack of level 1 evidence.

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          Author and article information

          Journal
          JAMA Oncology
          JAMA Oncol
          American Medical Association (AMA)
          2374-2437
          September 01 2017
          September 01 2017
          : 3
          : 9
          : 1222
          Affiliations
          [1 ]Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India
          [2 ]Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
          [3 ]Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
          [4 ]Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
          [5 ]Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
          Article
          10.1001/jamaoncol.2017.0324
          5824286
          28384657
          © 2017

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