Sorafenib Maintenance Appears Safe and Improves Clinical Outcomes in FLT3-ITD Acute Myeloid Leukemia After Allogeneic Hematopoietic Cell Transplantation.

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Abstract

The FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) gene is one of the most frequently observed genetic alterations in acute myeloid leukemia (AML), with an incidence of about 20% to 30%. FLT3-ITD is significantly associated with a poor outcome, and offering an allogeneic hematopoietic cell transplantation (allo-HCT) is recommended for patients harboring this mutation. Sorafenib is a tyrosine kinase inhibitor active against RAF, VEGF, and FLT3-ITD. It has been used in an off-label fashion in FLT3-ITD AML.

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Journal

Journal ID (iso-abbrev): Clin Lymphoma Myeloma Leuk

Title: Clinical lymphoma, myeloma & leukemia

ISSN (Electronic): 2152-2669

ISSN (Print): 2152-2669

Publication date (Electronic): May 2015

Volume: 15

Issue: 5

Affiliations

[1 ] Department of Internal Medicine/Hematology-Oncology, American University of Beirut Medical Center, Beirut, Lebanon.

[2 ] Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

[3 ] Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon.

[4 ] Department of Internal Medicine/Hematology-Oncology, American University of Beirut Medical Center, Beirut, Lebanon; Department of Cell Biology, Anatomy and Physiological Sciences, American University of Beirut, Beirut, Lebanon. Electronic address: bazarbac@aub.edu.lb.

Article

Publisher Item ID: S2152-2650(14)00540-0

DOI: 10.1016/j.clml.2014.12.005

PubMed ID: 25550214

SO-VID: d2652819-472a-4601-a9d3-2558f8b6209d

History

Keywords: AML,FLT3-ITD,Maintenance,Sorafenib,Stem Cell Transplantation

Data availability:

Keywords: AML, FLT3-ITD, Maintenance, Sorafenib, Stem Cell Transplantation

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