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Proton and photon radiosensitization effects of niraparib, a PARP-1/-2 inhibitor, on human head and neck cancer cells.
Li Wang
1 ,
Jianzhong Cao
1 ,
Xiaochun Wang
2 ,
Eric Lin
1 ,
Zeming Wang
2 ,
Yuting Li
2 ,
Yupeng Li
2 ,
Mei Chen
2 ,
Xianliang Wang
2 ,
Bo Jiang
2 ,
Ruiping Zhang
2 ,
Narayan Sahoo
2 ,
Xiaodong Zhang
2 ,
X Ronald Zhu
2 ,
Jeffrey N Myers
3 ,
Steven J Frank
4
September 2020
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Abstract
Combining photon or proton radiotherapy with targeted therapy shows promise for head and neck cancer (HNSCC). The poly (adenosine diphosphate [ADP]-ribose) polymerase-1/2 inhibitor niraparib targets DNA damage repair (DDR). We evaluated the effects of niraparib in combination with photons or protons, and its effects on the relative biological effectiveness (RBE) of protons, in human HNSCC cell lines.