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Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.
D D Ateh
1 ,
I K Hussain ,
A H Mustafa ,
K M Price ,
R Gulati ,
C D Nickols ,
M M Bird ,
L Greensmith ,
M Hafezparast ,
E M C Fisher ,
C S Baker ,
J E Martin
Feb 2008
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Abstract
The dynein-dynactin complex, mostly recognized for axonal retrograde transport in neurones, has an ever growing list of essential subcellular functions. Here, the distribution of complex subunits in human central nervous system (CNS) has been assessed using immunohistochemistry in order to test the hypothesis that this may be altered in neurodegenerative disease.