Autoimmune Insulin Syndrome in a Patient with Progressive Systemic Sclerosis Receiving Penicillamine

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Abstract

The case of a patient with progressive systemic sclerosis, who developed hypoglycaemia and insulin autoantibodies, is described. Repeated blood glucose measurements showed levels < 2.8 mmol/l. High immunoreactive insulin levels, with undetectable free insulin, led to the discovery of anti-insulin antibodies in the patient’s serum. He had no history of exogenous insulin use and was receiving penicillamine treatment. A double mechanism for the autoimmune insulin syndrome in this case is proposed: acting in a patient with increased humoral immunoresponsiveness, penicillamine might have induced the development of insulin autoantibodies.

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Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 03 December 2008

Volume: 37

Issue: 1-2

Pages: 78-80

Affiliations

Divisions of ^aEndocrinology, ^bBiochemistry, and ^cNephrology, Hospital La Paz, and ^dDivision of Endocrinology, Fundación Jimenez Diaz, Madrid, Spain

Article

Publisher ID: 182286 Other ID: Horm Res 1992;37:78–80

DOI: 10.1159/000182286

PubMed ID: 1398479

SO-VID: d437366f-64de-4846-af97-842679a8b43d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 November 1991

Date accepted : 25 February 1992

Page count

Pages: 3

Autoimmune Insulin Syndrome in a Patient with Progressive Systemic Sclerosis Receiving Penicillamine

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Karger: Endocrinology

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