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      Autoimmune Insulin Syndrome in a Patient with Progressive Systemic Sclerosis Receiving Penicillamine

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          The case of a patient with progressive systemic sclerosis, who developed hypoglycaemia and insulin autoantibodies, is described. Repeated blood glucose measurements showed levels < 2.8 mmol/l. High immunoreactive insulin levels, with undetectable free insulin, led to the discovery of anti-insulin antibodies in the patient’s serum. He had no history of exogenous insulin use and was receiving penicillamine treatment. A double mechanism for the autoimmune insulin syndrome in this case is proposed: acting in a patient with increased humoral immunoresponsiveness, penicillamine might have induced the development of insulin autoantibodies.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 37
          : 1-2
          : 78-80
          Divisions of aEndocrinology, bBiochemistry, and cNephrology, Hospital La Paz, and dDivision of Endocrinology, Fundación Jimenez Diaz, Madrid, Spain
          182286 Horm Res 1992;37:78–80
          © 1992 S. Karger AG, Basel

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          Pages: 3
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