Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.

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Abstract

The Secondary Prevention of Small Subcortical Stroke trial (SPS3) recruited participants meeting clinical and radiological criteria for symptomatic lacunes. Individuals randomized to dual antiplatelet therapy with clopidogrel and aspirin had an unanticipated increase in all-cause mortality compared with those assigned to aspirin. We investigated the factors associated with mortality in this well-characterized population.

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Author and article information

Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): Oct 2014

Volume: 45

Issue: 10

Affiliations

[1 ] From the Divisions of Neurology (M.S., R.G.H.) and Cardiology (S.J.C.), Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada; Biostatistics Consultant, Minot, ND (L.A.P.); Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); Department of Neurology, University of Minnesota, Minneapolis (D.C.A.); Department of Neurology, University of Texas Health Science Center, San Antonio (S.P.); and Department of Biostatistics, University of Iowa, Iowa City (C.S.C.). Mike.Sharma@phri.ca.

[2 ] From the Divisions of Neurology (M.S., R.G.H.) and Cardiology (S.J.C.), Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada; Biostatistics Consultant, Minot, ND (L.A.P.); Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (O.R.B.); Department of Neurology, University of Minnesota, Minneapolis (D.C.A.); Department of Neurology, University of Texas Health Science Center, San Antonio (S.P.); and Department of Biostatistics, University of Iowa, Iowa City (C.S.C.).

Article

Publisher Item ID: STROKEAHA.114.005789 Mid ID: NIHMS619113

DOI: 10.1161/STROKEAHA.114.005789

PMC ID: 4175186

PubMed ID: 25158772

SO-VID: d48e4748-5045-4d6a-9b8e-6f6cd5c3d3be

History

Keywords: stroke, lacunar,mortality

Data availability:

Keywords: stroke, lacunar, mortality

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