FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

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Abstract

Perhaps the most pressing need in cancer therapeutics is to understand drug resistance. In this issue of Cancer Cell, Hirata and colleagues show that melanoma-associated fibroblasts can drive resistance to the BRAF inhibitor PLX4720 by stimulating matrix production/remodeling, and, consequently, survival signaling in melanoma cells via β1-integrin, Src, and FAK.

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Journal

Journal ID (iso-abbrev): Cancer Cell

Title: Cancer cell

Publisher: Elsevier BV

ISSN (Electronic): 1878-3686

ISSN (Print): 1535-6108

Publication date (Electronic): Apr 13 2015

Volume: 27

Issue: 4

Affiliations

[1 ] Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address: m.frame@ed.ac.uk.

[2 ] Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

Article

Publisher Item ID: S1535-6108(15)00101-4

DOI: 10.1016/j.ccell.2015.03.013

PubMed ID: 25873166

SO-VID: d6b24f42-0cc3-42b0-890f-1302321f0eb6

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