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      Friendships and Family Support Reduce Subsequent Depressive Symptoms in At-Risk Adolescents

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          Abstract

          Background

          Early life stress (ELS) consists of child family adversities (CFA: negative experiences that happened within the family environment) and/or peer bullying. ELS plays an important role in the development of adolescent depressive symptoms and clinical disorders. Identifying factors that may reduce depressive symptoms in adolescents with ELS may have important public mental health implications.

          Methods

          We used structural equation modelling and examined the impact of adolescent friendships and/or family support at age 14 on depressive symptoms at age 17 in adolescents exposed to ELS before age 11. To this end, we used structural equation modelling in a community sample of 771 adolescents (322 boys and 477 girls) from a 3 year longitudinal study. Significant paths in the model were followed-up to test whether social support mediated or moderated the association between ELS and depressive symptoms at age 17.

          Results

          We found that adolescent social support in adolescence is negatively associated with subsequent depressive symptoms in boys and girls exposed to ELS. Specifically, we found evidence for two mediational pathways: In the first pathway family support mediated the link between CFA and depressive symptoms at age 17. Specifically, CFA was negatively associated with adolescent family support at age 14, which in turn was negatively associated with depressive symptoms at age 17. In the second pathway we found that adolescent friendships mediated the path between peer bullying and depressive symptoms. Specifically, relational bullying was negatively associated with adolescent friendships at age 14, which in turn were negatively associated with depressive symptoms at age 17. In contrast, we did not find a moderating effect of friendships and family support on the association between CFA and depressive symptoms.

          Conclusions

          Friendships and/or family support in adolescence mediate the relationship between ELS and late adolescent depressive symptoms in boys and girls. Therefore, enhancing affiliate relationships and positive family environments may benefit the mental health of vulnerable youth that have experienced CFA and/or primary school bullying.

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          Most cited references20

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          Stress, social support, and the buffering hypothesis.

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            Adult health outcomes of childhood bullying victimization: evidence from a five-decade longitudinal British birth cohort.

            The authors examined midlife outcomes of childhood bullying victimization.
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              Interventions to prevent child maltreatment and associated impairment.

              Although a broad range of programmes for prevention of child maltreatment exist, the effectiveness of most of the programmes is unknown. Two specific home-visiting programmes-the Nurse-Family Partnership (best evidence) and Early Start-have been shown to prevent child maltreatment and associated outcomes such as injuries. One population-level parenting programme has shown benefits, but requires further assessment and replication. Additional in-hospital and clinic strategies show promise in preventing physical abuse and neglect. However, whether school-based educational programmes prevent child sexual abuse is unknown, and there are currently no known approaches to prevent emotional abuse or exposure to intimate-partner violence. A specific parent-training programme has shown benefits in preventing recurrence of physical abuse; no intervention has yet been shown to be effective in preventing recurrence of neglect. A few interventions for neglected children and mother-child therapy for families with intimate-partner violence show promise in improving behavioural outcomes. Cognitive-behavioural therapy for sexually abused children with symptoms of post-traumatic stress shows the best evidence for reduction in mental-health conditions. For maltreated children, foster care placement can lead to benefits compared with young people who remain at home or those who reunify from foster care; enhanced foster care shows benefits for children. Future research should ensure that interventions are assessed in controlled trials, using actual outcomes of maltreatment and associated health measures.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                4 May 2016
                2016
                : 11
                : 5
                : e0153715
                Affiliations
                [1 ]Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
                [2 ]Faculty of Education, University of Cambridge, Cambridge, United Kingdom
                [3 ]Department of Psychology, University of Bath, Bath, United Kingdom
                [4 ]Department of Psychology, University of Exeter, Exeter, United Kingdom
                [5 ]Department of Psychology, University of Berne, Berne, Switzerland
                [6 ]School of Nursing and Health Sciences, University of Dundee, Dundee, Scotland, United Kingdom
                [7 ]Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
                West Virginia University School of Medicine, UNITED STATES
                Author notes

                Competing Interests: AlvH was supported by a Rubicon Fellowship from the Netherlands Organization for Scientific Research. IMG was supported by a Wellcome Trust programme grant, and grants from the NIHR Collaboration for Leadership in Applied Health Research, and Care (CLAHRC) for Cambridgeshire and Peterborough; IMG, AlvH, and JLG were supported through a grant from Kidscompany UK; PBJ was supported by Wellcome Trust grants, and National Institute for Health Research grant; RAK is supported by a Wellcome grant; JLG reports grants from ESRC, grants from MRC, grants, and personal fees from Royal College of Speech, and Language therapists. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The authors have declared that no competing interests exist.

                Conceived and designed the experiments: IG PBJ TC AlvH. Performed the experiments: VD. Analyzed the data: ALvH JB VD MS MO. Wrote the paper: ALvH JG MS MO JBGL VD TC PBJ RAK IMG.

                Article
                PONE-D-15-42268
                10.1371/journal.pone.0153715
                4856353
                27144447
                d6bbc6fd-abe0-4429-b81e-cb7af24a43ec
                © 2016 Harmelen et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 24 September 2015
                : 1 April 2016
                Page count
                Figures: 5, Tables: 3, Pages: 20
                Funding
                Funded by: Netherlands Organization for Scientific Research
                Award ID: 446-13-006
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
                Award Recipient :
                Funded by: NIHR
                Award Recipient :
                Funded by: CLAHRC
                Award Recipient :
                Funded by: KidsCompany
                Award Recipient :
                Funded by: Kidscompany
                Award Recipient :
                Funded by: KidsCompany
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/501100000272, National Institute for Health Research;
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/501100000272, National Institute for Health Research;
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/501100000269, Economic and Social Research Council;
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
                Award Recipient :
                Funded by: Royal College of Speech
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
                Award Recipient :
                AlvH received funding from the Netherlands Organization for Scientific Research (Rubicon grant NO 446-13-006). There are no other relationships or activities that could appear to have influenced the submitted work. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
                Categories
                Research Article
                People and Places
                Population Groupings
                Age Groups
                Adolescents
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Mood Disorders
                Depression
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Social Sciences
                Sociology
                Human Families
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Factor Analysis
                Physical Sciences
                Mathematics
                Statistics (Mathematics)
                Statistical Methods
                Factor Analysis
                Social Sciences
                Sociology
                Education
                Schools
                Social Sciences
                Economics
                Finance
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Psychological Stress
                Biology and Life Sciences
                Psychology
                Psychological Stress
                Social Sciences
                Psychology
                Psychological Stress
                Custom metadata
                The raw data and analysis code used for this manuscript will be available from www.annelauravanharmelen.com/ and on figshare ( https://figshare.com/authors/_/1376682).

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