Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries

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Abstract

Objective:

The aim of this study was to evaluate the association between lipid peroxidation and dental caries in children with ECC by estimating the levels of MDA in saliva of children.

Materials and Methods:

A total of 150 children were selected; 75 children with ECC and 75 children without caries (non-ECC). Saliva samples were collected and centrifuged at 12,000 rpm for 24 min at 4°C to obtain a supernatant. MDA levels were estimated by Buege and Aust method by using thiobarbituric acid. The data obtained were analyzed by Student's t-test to compare MDA levels between the groups.

Results:

MDA levels were higher in children with ECC. There was no statistically significant difference between children with ECC and without ECC (non-ECC).

Conclusion:

MDA levels were slightly higher in children with ECC, indicating the role of lipid peroxidation in the carious process.

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Most cited references 25

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Abstract: found
Article: found

Microsomal lipid peroxidation.

J A Buege, S D Aust (1978)

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Clinical Relevance of Biomarkers of Oxidative Stress

Jeroen Frijhoff, Paul G. Winyard, Neven Žarković … (2015)

Abstract Significance: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. Critical Issues: The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use. Future Directions: Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker. Antioxid. Redox Signal. 23, 1144–1170.

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Studies on free radicals, antioxidants, and co-factors

Khalid Rahman (2007)

The interplay between free radicals, antioxidants, and co-factors is important in maintaining health, aging and age-related diseases. Free radicals induce oxidative stress, which is balanced by the body’s endogenous antioxidant systems with an input from co-factors, and by the ingestion of exogenous antioxidants. If the generation of free radicals exceeds the protective effects of antioxidants, and some co-factors, this can cause oxidative damage which accumulates during the life cycle, and has been implicated in aging, and age dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders, and other chronic conditions. The life expectancy of the world population is increasing, and it is estimated that by 2025, 29% of the world population will be aged ≥60 years, and this will lead to an increase in the number of older people acquiring age-related chronic diseases. This will place greater financial burden on health services and high social cost for individuals and society. In order to acheive healthy aging the older people should be encouraged to acquire healthy life styles which should include diets rich in antioxidants. The aim of this review is to highlight the main themes from studies on free radicals, antioxidants and co-factors, and to propose an evidence-based strategy for healthy aging.

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Author and article information

Journal

Journal ID (nlm-ta): Eur J Dent

Journal ID (iso-abbrev): Eur J Dent

Journal ID (publisher-id): EJD

Title: European Journal of Dentistry

Publisher: Medknow Publications & Media Pvt Ltd (India )

ISSN (Print): 1305-7456

ISSN (Electronic): 1305-7464

Publication date (Print): Jan-Mar 2018

Volume: 12

Issue: 1

Pages: 67-70

Affiliations

[1 ]Department of Pediatric and Preventive Dentistry, Saveetha Dental College, Chennai, Tamil Nadu, India

[2 ]Department of Biochemistry, Saveetha Dental College, Chennai, Tamil Nadu, India

Author notes

Correspondence: Dr. Divya Subramanyam Email: smiley.divya24@ 123456gmail.com

Article

Publisher ID: EJD-12-67

DOI: 10.4103/ejd.ejd_266_17

PMC ID: 5883478

PubMed ID: 29657527

SO-VID: d6ed81d9-d965-443a-b309-f26a3e740b6b

License:

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries

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Abstract

Objective:

Materials and Methods:

Results:

Conclusion:

Related collections

Arab Journal of Forensic Sciences & Forensic Medicine (AJFSFM)

Most cited references 25

Microsomal lipid peroxidation.

Clinical Relevance of Biomarkers of Oxidative Stress

Studies on free radicals, antioxidants, and co-factors

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