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      Adherence to Antiretroviral Therapy and Associated Factors Among Children Living With HIV in East Wallaga Zone Public Health Institutions, Ethiopia

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          Abstract

          Background: Adherence to antiretroviral therapy (ART) in children is influenced by multiple factors that can be linked to carer and children. The study aimed to assess the level of adherence to ART and its associated factors among children attending ART in East Wallaga zone public health institutions, Ethiopia. Methods: An institution-based cross-sectional study was conducted among ART attending children in East Wallaga public health facilities. Pretested and structured questionnaires were used to collect data. To determine the level of significance, bivariate and multiple logistic regressions and 95% confidence intervals were performed. Results: One hundred eighty-five (78.1%) of the 237 study participants’ caregiver stated that their children had adhered to ART in the month preceding the interview. The male children, children from urban, disclosure the human immunodeficiency virus status to the children, proximity to health facilities, good relationship of caregivers with healthcare providers, and children on first-line regimens were strongly linked with ART adherence. Conclusion: The adherence rate obtained in this study was less than 95%, which is an optimal level of adherence recommended by the World Health Organization. Therefore, much work has to be done to optimize adherence to ART.

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          Persistent wandering atrial pacemaker after epinephrine overdosing – a case report

          Background Long-term complications of sympathomimetic drug overdosing have not been adequately investigated in infants and young children. Despite reports discouraging their use in children, these formulations are frequently administered for “cold-like symptoms”. Their frequent adverse events are different forms of arrhythmias, including multifocal atrial tachycardia. Case presentation A 3-year-old toddler developed multifocal atrial tachycardia following an iatrogenic overdose of epinephrine accidentally administered intravenously. His ECG showed wandering atrial pacemaker (p-waves with different origins and configurations) that persisted for at least one year. This event demonstrated the sensitivity of young children to the sympathomimetic drugs, especially overdosing. Conclusions Health care providers and parents should be warned of toxicities associated with sympathomimetic drug overdosing. Future studies are needed to determine whether wandering atrial pacemaker is a potential long-term complication of high-dose sympathomimetics.
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            Factors associated with adherence to antiretroviral therapy among HIV infected children in Kabale district, Uganda: a cross sectional study

            Objectives This study was set out to assess the level of adherence to antiretroviral therapy (ART) and its determinants among children receiving HIV treatment in Kabale district, south western Uganda, in order to inform interventions for improving pediatric ART adherence. Results Overall, 79% (121/153) of the children did not miss ART doses over the 7 days. Caregiver forgetfulness was the major reason for missing ART doses, 37% (13/35). Other reasons included transportation costs to the health facilities, 17%, (6/35) and children sitting for examinations in schools. Older children (11–14 years) were more likely to adhere to ART than the younger ones (0–10 years) (AOR = 6.41, 95% CI 1.31–31.42). Caregivers, who knew their HIV status, had their children more adherent to ART than the caregivers of unknown HIV status (AOR = 21.64: 95% CI 1.09–428.28). A significant proportion of children in two facilities 21.5% (32/153) missed ART doses within the previous week. Support for providers to identify clues or reminders to take drugs, extending HIV testing to caregivers and innovative models of ART delivery that alleviate transport costs to caregivers and allow sufficient drugs for children in school could enhance drug adherence among children.
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              Medication Adherence and its Determinants Among Patients on Concomitant Tuberculosis and Antiretroviral Therapy in South West Ethiopia

              Background: To benefit from therapy and to avoid contracting treatment resistant strains, the individuals must adhere to medications. Aim: The study was designed to assess the degree of drug adherence and its determinants in patients living with HIV/AIDS and TB comorbidity. Materials and Methods: A cross-sectional study was conducted to assess the degree of drug adherence and its determinants with the help of self-administered questionnaires in Tercha District Hospital in South Ethiopia. Result: A total of 24 patients were included in the study. The majority were females (54.2%) and the mean age was 32.4 (SD±9.6) years. Adherence level was 95.8% for Antiretroviral (ARV) medications and 79.2% for anti TB medications. Educational status was associated with anti TB (P=0.021) medication adherence. The reason for the missed doses were mostly lack of money for transport (23.7% for antiretroviral therapy (ART), 26.0% for TB treatment) and forgetting to take medications (18.4% for ART, 17.4% for TB treatment. Conclusion: The adherence level obtained for both ARV and anti-TB where high. Transportation costs for patients could be reduced by bringing the services close to where they live.
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                Author and article information

                Journal
                J Int Assoc Provid AIDS Care
                J Int Assoc Provid AIDS Care
                JIA
                spjia
                Journal of the International Association of Providers of AIDS Care
                SAGE Publications (Sage CA: Los Angeles, CA )
                2325-9574
                2325-9582
                20 November 2023
                Jan-Dec 2023
                : 22
                : 23259582231215677
                Affiliations
                [1 ]Nekemte Specialized Hospital, Nekemte, Ethiopia
                [2 ]Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia
                [3 ]Department of Medical Laboratory Sciences, Institute of Health Sciences, Ringgold 128159, universityWollega University; , Nekemte, Ethiopia
                Author notes
                [*]Milkias Abebe, Department of Medical Laboratory Sciences, Institute of Health Sciences, Wollega University, Nekemte, P. Box: 395, Ethiopia. Email: mickyelfe21@ 123456gmail.com
                Author information
                https://orcid.org/0000-0002-7437-5724
                Article
                10.1177_23259582231215677
                10.1177/23259582231215677
                10664416
                d849d1be-2d61-4efc-b926-456442ac84dc
                © The Author(s) 2023

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                : 11 July 2023
                : 9 October 2023
                : 4 November 2023
                Categories
                Original Research Article
                Custom metadata
                ts19
                January-December 2023

                antiretroviral therapy,antiviral,hiv,treatment,africa
                antiretroviral therapy, antiviral, hiv, treatment, africa

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