5
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Inativação fotodinâmica de microrganismos Translated title: Photodynamic inactivation of microorganisms

      research-article
      1
      Química Nova
      Sociedade Brasileira de Química
      photodynamic inactivation, microorganisms, dyes

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Translated abstract

          Photodynamic Therapy uses photosensitive dyes and visible light that, combined in the presence of oxygen, produce cytotoxic species that cause tumor death. Microorganisms such as bacteria, fungi, yeasts and viruses (including HIV) can also be inactivated by visible light after treatment with an appropriate photosensitizer as an alternative low cost treatment for localized infections, viral lesions such as acnes, and fungical skin lesions for example. Besides, Photodynamic Inactivation can be used for sterilization of blood and its subproducts for clinical use, in the treatment of drinking water as well as in antimicrobial detoxification of foods.

          Related collections

          Most cited references80

          • Record: found
          • Abstract: found
          • Article: not found

          Proteasome inhibitors block development of Plasmodium spp.

          Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S proteasome, inhibit development of the exoerythrocytic and erythrocytic stages of the malaria parasite. Although lactacystin-treated Plasmodium berghei sporozoites are still invasive, their development into exoerythrocytic forms (EEF) is inhibited in vitro and in vivo. Erythrocytic schizogony of P. falciparum in vitro is also profoundly inhibited when drug treatment of the synchronized parasites is prior, but not subsequent, to the initiation of DNA synthesis, suggesting that the inhibitory effect of lactacystin is cell cycle specific. Lactacystin reduces P. berghei parasitemia in rats, but the therapeutic index is very low. Along with other studies showing that lactacystin inhibits stage-specific transformation in Trypanosoma and Entamoeba spp., these findings highlight the potential of proteasome inhibitors as drugs for the treatment of diseases caused by protozoan parasites.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffolds.

            Growing and differentiating human stem cells in vitro can provide access to study the molecular mechanisms that control cellular development in a manner pertinent to human embryogenesis. To fully understand such processes, however, it is important to recreate culture conditions that most closely relate to those in living tissues. As step in this direction, we have developed a robust three-dimensional cell culture system using inert highly porous solid matrices manufactured from polystyrene that can be routinely used to study the differentiation of human pluripotent stem cell-derived neurons in vitro. Neurite outgrowth was significantly enhanced when neurons were grown in a three-dimensional environment compared to traditional flat surfaces and resulted in the formation of extensive neural networks. These data suggest that the topography within the culture environment can significantly alter cell development and will therefore be an important feature when investigating the potential of human stem cells.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Antimicrob. Agents Chemother.

                Bookmark

                Author and article information

                Contributors
                Role: ND
                Journal
                qn
                Química Nova
                Quím. Nova
                Sociedade Brasileira de Química (São Paulo )
                1678-7064
                August 2007
                : 30
                : 4
                : 988-994
                Affiliations
                [1 ] Universidade de São Paulo Brazil
                Article
                S0100-40422007000400039
                10.1590/S0100-40422007000400039
                d86a121a-bf03-4d97-aad7-09226262f1cf

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-4042&lng=en
                Categories
                CHEMISTRY, MULTIDISCIPLINARY

                General chemistry
                photodynamic inactivation,microorganisms,dyes
                General chemistry
                photodynamic inactivation, microorganisms, dyes

                Comments

                Comment on this article