Recovery from substance use is a vital concern for many women with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). This qualitative study explores the meaning of women's HIV infection for their transition from drug use to recovery. Interviews were conducted with 15 female clients of a drug treatment program and AIDS nursing home in New York City. For most participants, HIV did not constitute the main reason for starting their recovery. The dual diagnosis program, however, facilitates an important transformation of the meaning of HIV/AIDS. Previously viewed as just another reason to use drugs, women now increasingly perceive their HIV infection as an incentive to stay clean and sober.