Detection of Angiostrongylus malaysiensis circulating antigen using monoclonal antibody-based enzyme-linked immunosorbent assay (MAb-ELISA).

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Abstract

Three MAbs 1C4.2D8, 1C4.2C4 and 1C4.1F5 were produced using sonicated adult worm antigens of Angiostrongylus malaysiensis and they were found to be secreters of IgG1. The MAbs 1C4.2C4 and 1C4.2D8 were found to react with antigens of A. malaysiensis and cross-react with the closely related A. cantonensis but not with other helminths. A total of 108 human sera collected from Orang Asli (aborigenes) from Grik, in the State of Perak were tested for A. malaysiensis infection using the MAb-ELISA. MAb 1C4.1F5 and 25 (23%) were positive. Twenty of these positive samples were tested with the MAb 1C4.2D8 and none was found to be positive.

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Journal

Journal ID (iso-abbrev): Southeast Asian J. Trop. Med. Public Health

Title: The Southeast Asian journal of tropical medicine and public health

ISSN: 0125-1562

ISSN (Print): 0125-1562

Publication date (Electronic): 1997

Volume: 28 Suppl 1

Affiliations

[1 ] Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.

Article

PubMed ID: 9656366

SO-VID: d8ec3b43-3eab-4efe-823d-cbecdbad9f17

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