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      Bilateral choroidal neovascularization response to unilateral intravitreal Ranibizumab injection in a patient with angioid streaks Translated title: Resposta de neovascularização bilateral de coróide à injeção unilateral de Ranibizumabe intravítreo de paciente com estrias angióides

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          Abstract

          Report of a 48 year-old male with bilateral decrease in vision due to choroidal neovascularization secondary to angioid streaks. Best corrected visual acuity was 20/80 in the right eye and counting fingers at 2 meters on the left eye. Patient underwent intravitreal injection of Ranibizumab (Lucentis) in the eye with worse visual acuity. Fifteen days after treatment patient reported better visual acuity on the fellow eye, which was measured to be 20/25. Treatment result was evaluated with visual acuity and optical coherence tomography. The effect of ranibizumab was observed in the treated eye, but the fellow eye had complete resolution of the choroidal neovascularization complex. This result may be a response to systemic absorption of the medication.

          Translated abstract

          Os autores descrevem paciente do sexo masculino, 48 anos, com diminuição visual bilateral há 15 dias por membrana neovascular sub-retiniana secundária a estrias angióides. A acuidade visual com melhor correção no olho direito era 20/80 e no olho esquerdo de conta dedos a 2 metros. Submetido à injeção intravítrea de Ranibizumabe (Lucentis) no olho com pior acuidade visual. Após 15 dias do tratamento, referiu melhora acentuada da visão no olho contralateral com visão de 20/25. O resultado foi avaliado por meio da acuidade visual e da tomografia de coerência óptica. O efeito do ranibizumabe foi observado no olho tratado, mas no olho contralateral houve completa resolução do complexo da membrana neovascular sub-retiniana. Levanta-se a hipótese de que esse resultado possa ser atribuído à absorção sistêmica da medicação.

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          Most cited references9

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          Management of Retinal Vascular and Macular Disorders

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            Pharmacokinetics and retinal distribution of ranibizumab, a humanized antibody fragment directed against VEGF-a, following intravitreal administration in rabbits

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              Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rbof
                Revista Brasileira de Oftalmologia
                Rev. bras.oftalmol.
                Sociedade Brasileira de Oftalmologia (Rio de Janeiro )
                1982-8551
                August 2013
                : 72
                : 4
                : 274-277
                Affiliations
                [1 ] Hospital São Rafael Brazil
                [2 ] Universidade de São Paulo Brazil
                [3 ] Fundação Terapêutica Monte Tabor Brazil
                [4 ] Universidade de São Paulo Brazil
                [5 ] Fundação Terapêutica Monte Tabor Brazil
                Article
                S0034-72802013000400014
                10.1590/S0034-72802013000400014
                d9121891-62c2-4732-b0aa-503bb710b6bb

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0034-7280&lng=en
                Categories
                OPHTHALMOLOGY

                Ophthalmology & Optometry
                Angioid streaks,Retinal diseases,Retina,Angiogenesis inhibitors,Estrias angióides,Doenças retinianas,Inibidores da angiogênese

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