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Clinicopathological and prognostic features of Epstein-Barr virus infection, microsatellite instability, and PD-L1 expression in gastric cancer.
Marina A Pereira
1 ,
Marcus F K P Ramos
1 ,
Sheila F Faraj
1 ,
Andre R Dias
1 ,
Osmar K Yagi
1 ,
Bruno Zilberstein
1 ,
Ivan Cecconello
1 ,
Venancio A F Alves
1 ,
Evandro S de Mello
1 ,
Ulysses Ribeiro
1
Apr 2018
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Abstract
Gastric cancer (GC) has recently been categorized in molecular subtypes, which include Epstein-Barr (EBV)-positive and microsatellite instability (MSI) tumors. This distinction may provide prognostic information and identifies therapeutic targets. The aim of this study was to evaluate EBV, MSI, and PD-L1 immunoexpression in GC and its relationship with clinicopathological characteristics and patient's prognosis.