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      Gonadal Effects of Pinealectomy and Immunization against N-acetylindolealkylamines in the Hamster

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          Abstract

          In order to determine whether circulating melatonin (MEL) is necessary for the gonadal regression seen in hamsters exposed to a short photoperiod, animals were immunized with N-acetylserotonin (NAS) conjugated to protein. Antibodies formed against this conjugate bind MEL and NAS equally. When exposed to a short photoperiod (L:D, 1:23), a dramatic regression was seen in gonadal weight with no effect on body, Harderian gland or adrenal weight. Plasma testosterone levels also dropped. Immunization against NAS did not modify these effects, suggesting that circulating MEL does not mediate the antigonadal effect of the short photoperiod.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 22
          : 4
          : 289-297
          Affiliations
          Neuroendocrinology and Neurochemistry Research Sections, Clarke Institute of Psychiatry, Toronto, Ont. and the Department of Psychiatry, University of Rochester, Rochester, N.Y.
          Article
          122637 Neuroendocrinology 1976;22:289–297
          10.1159/000122637
          1030497
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 9
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