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Abstract
Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and
efficacy of typically sparingly available antigen. Their concomitant critical importance
in mass vaccination programmes may have prompted recent intense interest in understanding
how they work and their safety. Progress in these areas is stymied, however, by a
lack of accessible knowledge pertaining to the bioinorganic chemistry of aluminium
adjuvants, and, consequently, the inappropriate application and interpretation of
experimental models of their mode of action. The objective herein is, therefore, to
identify the many ways that aluminium chemistry contributes to the wide and versatile
armoury of its adjuvants, such that future research might be guided towards a fuller
understanding of their role in human vaccinations.
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