Introduction
First described in 1994 by Kossard,
1
frontal fibrosing alopecia is characterized by scarring alopecia with gradual progressive
recession of the frontotemporal portion of the hairline, occurring anywhere from 0.4
to 1.7 mm per month.
2
This variant of lichen planopilaris is most commonly found in postmenopausal women
and is increasing in prevalence. In addition to hair loss, other features associated
with this condition include a band of thin, scarred skin with distinguished vessels,
sparse lone vellus hairs, and perifollicular erythema with surrounding fibrosis. Facial
papules are a synchronous finding present in 14% of patients with frontal fibrosing
alopecia, with profound effects on appearance.
3
The pathogenesis of these lesions is not fully understood and there are currently
no established treatments; however, theories involve inflammation of hair follicles,
dilated or enlarged sebaceous glands, or a combination of the 2.
Herein, we present 3 patients with frontal fibrosing alopecia with progressive hair
loss and concomitant facial papules who experienced hair loss stability and significant
improvement of facial papules with the use of oral isotretinoin. Severity of scalp
disease was graded 0 to 3 for presence and intensity of perifollicular scale, erythema,
and folliculitis.
Case series
Case 1
A 28-year-old woman presented with a 4-year history of biopsy-proven, progressive
frontal fibrosing alopecia with severe facial papule eruptions. Physical examination
revealed alopecia on the frontoparietal scalp and lateral eyebrows, with perifollicular
erythema, scale, and skin-colored papules on her forehead (Fig 1, A). The scalp condition
was scored as perifollicular scale 2+, erythema 2+, and folliculitis 2+. The patient
had previously failed a 6-month course of oral doxycycline and intralesional triamcinolone,
and at presentation had been receiving minocycline 100 mg by mouth twice daily for
6 months, without improvement. She began receiving oral isotretinoin 20 mg twice daily
in addition to her current hair treatment regimen: minoxidil 5% topically twice daily,
ketoconazole shampoo 2% topically 3 times per week, fluocinonide 0.05% solution topically
twice daily, and intralesional triamcinolone 5 mg/mL every 6 to 8 weeks. At 1-month
follow-up, she displayed decreased shedding and improvement in scalp scores, with
perifollicular scale 1+, erythema 1+, and folliculitis 1+. A significant decrease
in the number and size of her facial papules was also observed, along with hairline
stability, with continued remarkable improvement by month 6, when the dose was decreased
(Fig 1, B). The patient continued receiving therapy with isotretinoin 20 mg once a
day and currently has good control of disease and regrowth of eyebrows.
Fig 1
A and B, Facial papules in a female patient with frontal fibrosing alopecia before
isotretinoin treatment and with significant reduction after 6 months of treatment.
C and D, A male patient with frontal fibrosing alopecia before isotretinoin treatment
and with stabilization and decreased inflammation after 3 months of treatment.
Case 2
A 42-year-old man presented with a 5-year history of progressive frontal fibrosing
alopecia and lichen planopilaris as part of Graham-Little-Piccardi-Lasseur syndrome,
and with moderate to severe papules on the forehead, chest, neck, and back. The patient
also had a history of oral lichen planus and hypothyroidism currently treated with
a supplement. His previous treatments included topical and intralesional triamcinolone
and hydroxychloroquine, with continued progression of disease. He had also received
oral finasteride 1.25 mg daily, but reported sexual dysfunction after 2 weeks and
ceased treatment. Physical examination showed progressive hair loss on the frontal
portion of the hairline and 1- to 3-mm skin-colored papules present on the forehead
and face (Fig 1, C). Scalp examination scores were perifollicular scale 1+, erythema
1+, and folliculitis 1+, with medial thinning of eyebrows. Tacrolimus 0.1% topical
ointment was prescribed for the hairline and eyebrows. The patient began receiving
oral isotretinoin 30 mg daily, and in addition, he continued to receive intralesional
triamcinolone 5 mg/mL every 6 to 8 weeks. At 1-month follow-up, examination showed
reduction of scalp scores to erythema perifollicular scale 0, erythema 0/1+, and folliculitis
0/1+. At 3-month follow-up, examination showed hair loss stability, less inflammation
and redness on the scalp and eyebrows, and decreased hair shedding (Fig 1, D). Improvement
of papules was observed by month 6, with minor adverse effects including xerosis cutis
of the face and lips. The dose was then decreased to 30 mg every other day, and he
has not needed intralesional triamcinolone injections since. An 18-month follow-up
showed near-complete regrowth of eyebrows.
Case 3
A 65-year-old postmenopausal woman with a 2-year history of frontal fibrosing alopecia
and lichen planopilaris presented with facial papules, frontal hair loss, and evidence
of scalp inflammation with reported pruritus. Physical examination revealed frontal
and vertex scalp hair loss with significant perifollicular erythema and scale, and
numerous red and skin-colored papules on the frontotemporal portion of the forehead.
Scalp scores were recorded as perifollicular scale 2+, erythema 3+, and folliculitis
2+. The patient's eyelashes and eyebrows were scant. She began receiving isotretinoin
20 mg by mouth daily and continued with intralesional triamcinolone 5 mg/mL every
6 to 8 weeks and topical clobetasol 0.05% solution daily on the scalp. At 4- and 8-month
follow-up, the patient exhibited decreased hair shedding on the scalp, perifollicular
scale, erythema, folliculitis, and facial papules, whereas no eyebrow changes were
observed. Results were maintained at the 12-month follow-up, with self-reported eyelash
thickening at 2-year follow-up. The patient tolerated the medication well, with minor
adverse effects including xerosis of the lips.
Discussion
Isotretinoin is a vitamin A derivative traditionally used to treat moderate to severe
acne. In our case series of 3 patients, low-dose isotretinoin was effective for the
treatment of inflammation and facial papules associated with frontal fibrosing alopecia.
The mechanism of action of isotretinoin in stabilizing hair loss and decreasing inflammation
in frontal fibrosing alopecia is not clearly understood, but it has been proposed
that it normalizes follicular keratinocyte antigen expression and reduces inflammatory
cellular infiltrate. One retrospective study reported stabilization of the frontal
hairline with isotretinoin 20 mg by mouth daily for a mean treatment duration of 13.5 months
(range 12-16 months) in 76% of patients with frontal fibrosing alopecia (n = 23/29),
and 72% of those patients (n = 21/29) had no further progression of disease after
discontinuation of treatment when evaluated at 24 months.
4
In addition, a few studies have reported the use of isotretinoin for lichen planopilaris.
5
,
6
In 1 study, isotretinoin 1 mg/kg by mouth was given to 15 patients with treatment-resistant
lichen planopilaris. Resolution of inflammation was observed in 66.66% of patients
after 4 months of therapy.
6
Spano and Donovan
5
reported that 24% of patients (n = 5/21) with treatment-resistant lichen planopilaris
had at least 1 of the following after receiving a course of retinoids: improvement
in erythema, scaling, or hyperkeratosis; cessation of hair loss; and conversion from
positive to negative pull test result, with approximately 2 to 4 months until clinical
improvement. Twelve patients had received acitretin 25 to 50 mg, 8 had received isotretinoin
1 mg/kg, and 1 received both at different periods.
Facial papules and rosacea-like eruptions are present in a subset of patients with
frontal fibrosing alopecia.
3
These papules most commonly are keratotic, presenting as skin roughness on the forehead
and frontotemporal portion of the scalp; however, they have also been reported on
the chest, back, and extremities.
7
The pathogenesis of facial papules in frontal fibrosing alopecia remains unclear.
3
,
8
,
9
Histologic examination demonstrates mild follicular hyperkeratosis and lichenoid dermatitis
involving the infundibulum and isthmus of vellus hair follicles with or without fibrosis,
similar to findings observed in lichen planopilaris.
10
,
11
However, other reports dispute the involvement of vellus hairs and show abundant sebaceous
glands and dilatated ducts, with reduction of overlying elastic fibers, but no vellus
hair that contributes to formation of papules.
12
These various histologic findings raise the possibility of different types of papules
involved in frontal fibrosing alopecia, or different stages of evolution of the same
inflammatory process. It is possible that vellus hair follicles were present and destroyed
by the inflammation, leaving only hypertrophic sebaceous glands that became raised
because of an overlying atrophic epidermis.
9
,
13
One proposed mechanism of action of isotretinoin therapy in treating facial papules
is through the reduction of sebum production, sebaceous gland size, and colonization
of propionibacterium acnes. The rapid response of facial papules after the use of
low-dose isotretinoin in these 3 patients corroborates this theory. Clinical reduction
of facial papules was observed as early as 2 weeks, with excellent responses observed
after 1 to 4 months of isotretinoin use. The duration of therapy remains to be established
because these patients are being carefully tapered off their dose.
Conclusion
A subset of patients with frontal fibrosing alopecia has concomitant facial papules
in addition to progressive hair loss. Low-dose isotretinoin can be used as a treatment
to control facial papules and scalp inflammation associated with frontal fibrosing
alopecia. Further large-scale studies with long-term follow-up are necessary to confirm
efficacy and determine dosing guidelines.