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      Two New Clerodane Diterpenes from Tinospora sagittata

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          Abstract

          Two new clerodane-type diterpenes, tinosporins C ( 1) and tinosporins D ( 2) were isolated from the stems of Tinospora sagittata (Oliv.), together with three known ones, columbin ( 3), tinophylloloside ( 4), and tinospinoside D ( 5). The structures of these compounds were determined on the basis of spectroscopic data interpretation, with that of the absolute configuration of compound 1 was assigned by experimental and calculated ECD spectra. The cytotoxicity and α-glucosidase inhibitory activities of isolated compounds were evaluated in vitro.

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          Corner flapping: a simple and fast algorithm for exhaustive generation of ring conformations

          Eiji Osawa, Hitoshi Goto (1989)
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            An efficient algorithm for searching low-energy conformers of cyclic and acyclic molecules

            Hitoshi Goto, Eiji Osawa (1993)
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              Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.

              Xiaohua Liu, Zhenlin Hu, Qirong Shi … (2010)
              Article 0 comments Cited 13 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Derek J. McPhee: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 19 September 2016
                Publication date Collection: September 2016
                Volume: 21
                Issue: 9
                Electronic Location Identifier: 1250
                Affiliations
                [1 ]College of Plant Protection, Hunan Agricultural University, Changsha 410128, China; liguanhua@ 123456hunau.edu.cn (G.L.); dingwenb119@ 123456hunau.edu.cn (W.D.); wanfanghao@ 123456caas.cn (F.W.)
                [2 ]Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China
                [3 ]State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
                Author notes
                [* ]Correspondence: liyouzhi@ 123456hunau.edu.cn ; Tel./Fax: +86-731-8461-8163
                [†]

                These authors contributed equally to this work.

                Article
                Publisher ID: molecules-21-01250
                DOI: 10.3390/molecules21091250
                PMC ID: 6274121
                PubMed ID: 27657021
                SO-VID: dc75d2ae-8e5a-46a8-86b5-1e24a07f0b3b
                Copyright © © 2016 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 24 August 2016
                Date accepted : 16 September 2016
                Categories
                Subject: Communication

                Keywords: tinospora sagittata,clerodane diterpenes,α-glucosidase inhibitory activity
                Data availability:
                Keywords: tinospora sagittata, clerodane diterpenes, α-glucosidase inhibitory activity

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