TRPML1-/TFEB-Dependent Regulation of Lysosomal Exocytosis.

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Abstract

Emerging experimental evidences indicate that the lysosome can trigger a calcium signaling, via TRPML1/calcineurin/TFEB pathway, that promotes lysosomal exocytosis and clearance of lysosomal accumulation in various cellular models of lysosomal storage disorders (LSDs). Here, we described methods to determine TFEB activation and lysosomal exocytosis that may represent innovative tools to study lysosomal function and to develop novel therapeutic approaches to promote clearance in LSDs.

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Author and article information

Journal

Journal ID (iso-abbrev): Methods Mol Biol

Title: Methods in molecular biology (Clifton, N.J.)

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1940-6029

ISSN (Print): 1064-3745

Publication date (Electronic): 2019

Volume: 1925

Affiliations

[1 ] Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, NA, Italy.

[2 ] Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, NA, Italy. medina@tigem.it.

Article

DOI: 10.1007/978-1-4939-9018-4_12

PubMed ID: 30674023

SO-VID: dc989e11-b426-4874-9242-0d73e2a280e8

History

Keywords: Autophagy,Calcineurin,LSDs,Lysosomal calcium,TFEB

Data availability:

Keywords: Autophagy, Calcineurin, LSDs, Lysosomal calcium, TFEB

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