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      Effects of Diet on Sleep: A Narrative Review

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          Abstract

          Many processes are involved in sleep regulation, including the ingestion of nutrients, suggesting a link between diet and sleep. Aside from studies investigating the effects of tryptophan, previous research on sleep and diet has primarily focused on the effects of sleep deprivation or sleep restriction on diet. Furthermore, previous reviews have included subjects with clinically diagnosed sleep-related disorders. The current narrative review aimed to clarify findings on sleep-promoting foods and outline the effects of diet on sleep in otherwise healthy adults. A search was undertaken in August 2019 from the Cochrane, MEDLINE (PubMed), and CINAHL databases using the population, intervention, control, outcome (PICO) method. Eligible studies were classified based on emerging themes and reviewed using narrative synthesis. Four themes emerged: tryptophan consumption and tryptophan depletion, dietary supplements, food items, and macronutrients. High carbohydrate diets, and foods containing tryptophan, melatonin, and phytonutrients (e.g., cherries), were linked to improved sleep outcomes. The authors posit that these effects may be due in part to dietary influences on serotonin and melatonin activity.

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          Most cited references55

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          Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.

          Links between short sleep duration and obesity, type 2 diabetes, hypertension, and cardiovascular disease may be mediated through changes in dietary intake. This review provides an overview of recent epidemiologic studies on the relations between habitual short sleep duration and dietary intake in adults from 16 cross-sectional studies. The studies have observed consistent associations between short sleep duration and higher total energy intake and higher total fat intake, and limited evidence for lower fruit intake, and lower quality diets. Evidence also suggests that short sleepers may have irregular eating behavior deviating from the traditional 3 meals/d to fewer main meals and more frequent, smaller, energy-dense, and highly palatable snacks at night. Although the impact of short sleep duration on dietary intake tends to be small, if chronic, it may contribute to an increased risk of obesity and related chronic disease. Mechanisms mediating the associations between sleep duration and dietary intake are likely to be multifactorial and include differences in the appetite-related hormones leptin and ghrelin, hedonic pathways, extended hours for intake, and altered time of intake. Taking into account these epidemiologic relations and the evidence for causal relations between sleep loss and metabolism and cardiovascular function, health promotion strategies should emphasize improved sleep as an additional factor in health and weight management. Moreover, future sleep interventions in controlled studies and sleep extension trials in chronic short sleepers are imperative for establishing whether there is a causal relation between short sleep duration and changes in dietary intake.
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            L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

            An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan’s role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophan supplementation. The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. As the sole precursor of serotonin, experimental research has shown that L-tryptophan’s role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. Furthermore, clinical trials have provided some initial evidence of L-tryptophan’s efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents.
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              Restoration of brain energy metabolism as the function of sleep.

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                Author and article information

                Journal
                Nutrients
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                27 March 2020
                April 2020
                : 12
                : 4
                : 936
                Affiliations
                [1 ]Central Queensland University, School of Health, Medical and Applied Sciences, Melbourne 3000, Victoria, Australia; hannah.binks@ 123456cqumail.com
                [2 ]Central Queensland University, Appleton Institute, Adelaide 5034, South Australia, Australia; g.vincent@ 123456cqu.edu.au (G.E.V.); c.gupta@ 123456cqu.edu.au (C.G.)
                [3 ]Griffith University, School of Allied Health Sciences, Menzies Health Institute Queensland, Gold Coast 4222, Queensland, Australia; c.irwin@ 123456griffith.edu.au
                [4 ]Central Queensland University, School of Health, Medical and Applied Sciences and Appleton Institute, Brisbane 4000, Queensland, Australia
                Author notes
                [* ]Correspondence: s.khalesi@ 123456cqu.edu.au ; Tel.: +61-7-3023-4153
                Author information
                https://orcid.org/0000-0002-5508-8746
                https://orcid.org/0000-0002-7036-7823
                https://orcid.org/0000-0003-2436-3327
                https://orcid.org/0000-0002-1379-4271
                https://orcid.org/0000-0002-8208-2518
                Article
                nutrients-12-00936
                10.3390/nu12040936
                7230229
                32230944
                dcadc5f9-8512-499e-8c52-a15d7003a270
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 29 January 2020
                : 25 March 2020
                Categories
                Review

                Nutrition & Dietetics
                sleep quality,sleep duration,nutrients,dietary supplements,food,adults
                Nutrition & Dietetics
                sleep quality, sleep duration, nutrients, dietary supplements, food, adults

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