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      First results of a refeeding program in a psychiatric intensive care unit for patients with extreme anorexia nervosa

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          Abstract

          Background

          Anorexia nervosa (AN) is associated with a high mortality rate. This study describes a compulsory re-feeding program established in Munich for extremely underweight patients.

          Methods

          The contract between the patient and the therapeutic team included mandatory inpatient status, establishment of guardianship and compulsory re-feeding with a percutaneous gastric feeding tube, as indicated. The predefined target was a body mass index (BMI) of 17 kg/m 2. Data on the first 68 patients with AN are presented.

          Results

          65 (95.6%) patients were female and mean age at admission was 26.5 ± 8.5 years. BMI increased from 12.3 ± 1.4 kg/m 2 at admission to 16.7 ± 1.7 kg/m 2 at discharge. Thirty-two (47.1%) patients had the restrictive subtype (ANR) and 36 (52.9%) had the binging and purging subtype (ANBP). Duration of illness before admission (p = .004), days of treatment until discharge (p = .001) and weight increase (p = .02) were significantly different between subgroups in favor of patients with ANR. Also, seasonal differences could be found. Comparison of feeding methods showed that percutaneous tube feeding was superior. Almost half of the patients were treated with psychotropic medication. To date, however, the number of patients included in this program is too small to assess rare complications of this acute treatment program and long term outcomes of AN.

          Conclusions

          An intensive care program for severely ill AN patients has been successfully established. Besides averting physical harm in the short term, this program was designed to enable these patients to participate in more sophisticated psychotherapeutic programs afterwards. To our knowledge, this is the first such program that regularly uses percutaneous feeding tubes.

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          Most cited references35

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          Review of the prevalence and incidence of eating disorders.

          To review the literature on the incidence and prevalence of eating disorders. We searched Medline using several key terms relating to epidemiology and eating disorders and we checked the reference lists of the articles that we found. Special attention has been paid to methodologic problems affecting the selection of populations under study and the identification of cases. An average prevalence rate for anorexia nervosa of 0.3% was found for young females. The prevalence rates for bulimia nervosa were 1% and 0.1% for young women and young men, respectively. The estimated prevalence of binge eating disorder is at least 1%. The incidence of anorexia nervosa is 8 cases per 100,000 population per year and the incidence of bulimia nervosa is 12 cases per 100,000 population per year. The incidence of anorexia nervosa increased over the past century, until the 1970s. Only a minority of people who meet stringent diagnostic criteria for eating disorders are seen in mental health care. Copyright 2003 by Wiley Periodicals, Inc. Int J Eat Disord 34: 383-396, 2003.
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            Emotional functioning in eating disorders: attentional bias, emotion recognition and emotion regulation.

            Interpersonal processes, anxiety and emotion regulation difficulties form a key part of conceptual models of eating disorders (EDs), such as anorexia nervosa (AN) and bulimia nervosa (BN), but the experimental findings to support this are limited. The Reading the Mind in the Eyes task, the Difficulties in Emotion Regulation Scale (DERS) and a computerized pictorial (angry and neutral faces) Stroop task were administered to 190 women [50 with AN, 50 with BN and 90 healthy controls (HCs)]. Those with an ED showed attentional biases to faces in general (medium effect), but specifically to angry faces over neutral faces (large effect) compared to HCs. The ED group also reported significantly higher emotion regulation difficulties (large effect) than HCs. There was a small difference between the ED and HC groups for the emotion recognition task (small-medium effect), particularly in the restricting AN (RAN) group. Depression and attentional bias to faces significantly predicted emotion regulation difficulties in a regression model. The data provide support for conceptualizations of EDs that emphasize the role of emotional functioning in the development and maintenance of EDs. Further research will concentrate on exploring whether these findings are state or trait features of EDs.
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              Mortality in anorexia nervosa.

              The author's goal was to shed light on the debate regarding the mortality rate over time associated with anorexia nervosa. He conducted a meta-analytic study using weighted linear regression to combine crude mortality proportions from 42 published studies to estimate the mortality associated with anorexia nervosa over time. The crude rate of mortality due to all causes of death for subjects with anorexia nervosa in these studies was 5.9% (178 deaths in 3,006 subjects). The aggregate mortality rate was estimated to be 0.56% per year, or approximately 5.6% per decade. The aggregate estimated mortality rate for subjects with anorexia nervosa is substantially greater than that reported for female psychiatric inpatients and for the general population.
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                Author and article information

                Contributors
                christoph.born@med.uni-muenchen.de
                larissa.fontaine@med.uni-muenchen.de
                bwinter@tridoc-consulting.de
                norbert.mueller@med.uni-muenchen.de
                aschaub@med.uni-muenchen.de
                clemens.fruestueck@med.uni-muenchen.de
                cornelius.schuele@med.uni-muenchen.de
                uvoderholzer@schoen-kliniken.de
                ucuntz@schoen-kliniken.de
                peter.falkai@med.uni-muenchen.de
                eva.meisenzahl@med.uni-muenchen.de
                Journal
                BMC Psychiatry
                BMC Psychiatry
                BMC Psychiatry
                BioMed Central (London )
                1471-244X
                24 March 2015
                24 March 2015
                2015
                : 15
                : 57
                Affiliations
                [ ]Department of Psychiatry, Ludwig Maximilians-University, Nussbaumstrasse. 7, 80336 Munich, Germany
                [ ]Schoen-Klinik Roseneck, Prien am Chiemsee, Germany
                Article
                436
                10.1186/s12888-015-0436-7
                4374588
                dcd08da6-796c-428c-ab91-d050c9f31d17
                © Born et al.; licensee BioMed Central. 2015

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 9 September 2014
                : 9 March 2015
                Categories
                Research Article
                Custom metadata
                © The Author(s) 2015

                Clinical Psychology & Psychiatry
                eating disorders,anorexia nervosa,refeeding,percutaneous gastric feeding tube,high caloric solution

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