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      Recent progress of in situ formed gels for biomedical applications

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      Progress in Polymer Science
      Elsevier BV

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          Hydrogels for tissue engineering.

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            Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology

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              A logic-gated nanorobot for targeted transport of molecular payloads.

              We describe an autonomous DNA nanorobot capable of transporting molecular payloads to cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its structure for payload delivery. The device can be loaded with a variety of materials in a highly organized fashion and is controlled by an aptamer-encoded logic gate, enabling it to respond to a wide array of cues. We implemented several different logical AND gates and demonstrate their efficacy in selective regulation of nanorobot function. As a proof of principle, nanorobots loaded with combinations of antibody fragments were used in two different types of cell-signaling stimulation in tissue culture. Our prototype could inspire new designs with different selectivities and biologically active payloads for cell-targeting tasks.
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                Author and article information

                Journal
                Progress in Polymer Science
                Progress in Polymer Science
                Elsevier BV
                00796700
                March 2013
                March 2013
                : 38
                : 3-4
                : 672-701
                Article
                10.1016/j.progpolymsci.2012.08.002
                de8e060b-1918-43e2-ad50-addca9bbead2
                © 2013

                http://www.elsevier.com/tdm/userlicense/1.0/

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