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      The economic burden of inpatient care of depression in Poznan (Poland) and Kiel (Germany) in 2016

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          Abstract

          Depression is a global health problem associated with a significant public health burden and costs. Although studies on costs of diseases are being considered as an increasingly important factor for health policies, information concerning costs of inpatient care of depression is still insufficient. Thus, the main aim of this study was to evaluate costs of hospitalization of patients treated in 2016 in psychiatric clinics in Poznan (Poland) and in Kiel (Germany) and to analyze treatment used in these centers. The study was conducted from September 2017 to February 2018. 545 hospital records were considered (187 in Poznan and 358 in Kiel). Eventually, 490 hospital records were included, 168 in Poland and 322 in Germany. In general, the costs were calculated based on the patients’ sex and diagnosis (F32 and F33) separately and, subsequently, the outcomes were added and multiplied by the length of hospital stay, giving the cost of hospitalization. The annual cost of inpatient care of depression in 2016 was EUR 491,067.19 (

          ) in Poznan and EUR 2,847,991.00
          in Kiel. In Poznan, hospitalization was underfunded reaching EUR 183,042.55 (37.27% of total costs in Poznan). In Poznan, the most frequently prescribed medicine was quetiapine, followed by olanzapine and venlafaxine, whereas in Kiel it was venlafaxine, followed by mirtazapine and promethazine. Although non-pharmacological therapies were commonly used in both centers, in Kiel this type of treatment was better structured. The study confirms the degree of the economic burden of inpatient care of depression. The underfunding of mental health revealed, emphasizes the need for urgent amendment of organization and funding of mental health care in Poland. Patients in Poznan were hospitalized on average 10 days longer than in Kiel, thus a reduction of length of hospitalization in Poznan seems possible. Although pharmacotherapy seemed to be comprehensive in both centers, there were some differences between Poznan and Kiel. Access to non-pharmacological therapies during outpatient care was limited in Poznan, however, compared to Kiel.

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          Rates and correlates of employment in people with schizophrenia in the UK, France and Germany.

          Little is known about international variations in employment rates among people with schizophrenia or about the factors associated with employment in this disorder. To describe employment patterns and the variables associated with working in an international sample of people with schizophrenia. An analysis was made of baseline data from the European Schizophrenia Cohort study, a 2-year investigation of people with schizophrenia in contact with secondary services and living in France, Germany and the UK (n=1208). Participants were working in all sections of the job market. People who had a degree, were living with their families or had experienced only a single episode of illness were more likely to be working. A continuous illness course, more severe non-psychotic symptoms and drug misuse reduced the odds of employment. There were large variations between centres in employment rates, which were highest in the three German study sites. These differences persisted after adjustment for individual characteristics. Local social contexts may be as important as individual or illness-related factors in explaining employment status.
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            Cost of depression among adults in England in 2000.

            The cost of depression in the UK was estimated at pound 3.5 billion almost a decade ago. The shift to community-based management for depression alongside the availability of more accurate data have allowed these estimates to be revised. To calculate the total cost of depression in adults in England during 2000. Recorded data on health service use by patients with depression were analysed and the cost of treating patients was calculated. The cost of working life lost was estimated from sickness benefit claims and the number of registered deaths of patients with depression. The total cost of adult depression was estimated at over pound 9 billion, of which pound 370 million represents direct treatment costs. There were 109.7 million working days lost and 2615 deaths due to depression in 2000. Despite awareness campaigns and the availability of effective treatments, depression remains a considerable burden on both society and the individual, especially in terms of incapacity to work.
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              The impact of supported employment and working on clinical and social functioning: results of an international study of individual placement and support.

              Concerns are frequently expressed that working might worsen the mental health of people with severe mental illness (SMI). Several studies of Individual Placement and Support (IPS), however, have found associations between working and better nonvocational outcomes. IPS has been found to double the return to work of people with SMI in 6 European countries. To explore separately associations between IPS, returning to work, and clinical and social outcomes. Patients (n = 312) in a randomized controlled trial of IPS in 6 European centers were followed up for 18 months. There were no differences in clinical and social functioning between IPS and control patients at 18 months. Those who worked had better global functioning, fewer symptoms, and less social disability at final follow-up; greater job tenure was associated with better functioning. Working was associated with concurrently better clinical and social functioning, but this contrast was stronger in the control group, suggesting that IPS was better than the control service at helping more unwell patients into work. Working was associated with having been in remission and out of hospital for the previous 6 months. It was also associated with a slight decrease in depression and with being in remission over the subsequent 6 months. Concerns among clinicians about possible detrimental effects of working and supported employment have been misplaced. Although some of the associations found may have been selection effects, there is sufficient evidence of work having beneficial effects on clinical and social functioning to merit further exploration.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: InvestigationRole: Writing – review & editing
                Role: Formal analysis
                Role: Data curationRole: Investigation
                Role: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                14 June 2018
                2018
                : 13
                : 6
                : e0198890
                Affiliations
                [1 ] Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Poznan, Poland
                [2 ] Department of Psychiatry and Psychotherapy, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany
                [3 ] Department of Adult Psychiatry, Karol Jonscher Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
                Jagiellonian University, POLAND
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0001-9737-9624
                Article
                PONE-D-18-06852
                10.1371/journal.pone.0198890
                6001949
                29902259
                ded9bfd2-0766-4dac-a2db-1d333f047a15
                © 2018 Zaprutko et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 5 March 2018
                : 25 May 2018
                Page count
                Figures: 0, Tables: 5, Pages: 14
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/501100004281, Narodowe Centrum Nauki;
                Award ID: 503-19-03316440-30055-10596
                Award Recipient :
                The project was supported by a grant (503-19-03316440-30055-10596) from the National Science Centre, Poland. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Mood Disorders
                Depression
                Medicine and Health Sciences
                Health Care
                Patients
                Inpatients
                Medicine and Health Sciences
                Pharmaceutics
                Drug Therapy
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Hospitals
                Hospitalizations
                Social Sciences
                Economics
                Health Economics
                Medicine and Health Sciences
                Health Care
                Health Economics
                Social Sciences
                Economics
                People and places
                Geographical locations
                Europe
                European Union
                Poland
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Hospitals
                Custom metadata
                All relevant data are within the paper and its Supporting Information files.

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