MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1.

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Abstract

Increasing evidence has indicated that microRNAs (miRNAs) are strongly implicated in the initiation and progression of glioblastoma multiforme (GBM). Here, we identiﬁed a novel tumor suppressive miRNA, miR-377, and investigated its role and therapeutic effect for GBM.

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Author and article information

Journal

Journal ID (iso-abbrev): Neuro-oncology

Title: Neuro-oncology

ISSN (Electronic): 1523-5866

ISSN (Print): 1522-8517

Publication date (Electronic): Nov 2014

Volume: 16

Issue: 11

Affiliations

[1 ] Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (R.Z., H.L., W.C., Z.C., Q.D., Y.Z., Y.Y., N.L., H.W.); Department of Hematology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (S.W.); Department of Neurosurgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, China (H-W.W.); State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai, China (Y.C., J.Y., D.L.); Department of Molecular Human Genetics, Baylor College of Medicine, Houston, Texas (X.Z.); Beyster Center for Genomics of Psychiatric Diseases, Department of Psychiatry, University of California San Diego, La Jolla, California (W.W.); School of Radiation Medicine and Protection, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China (S-Y.Z.); Institute of Biochemistry, Zhejiang University, Hangzhou, China (S.S.); Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China (T.J.); Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China (S.Z.); Chinese Glioma Cooperative Group (T.J., Y.Y., N.L., H.W.).

Article

Publisher Item ID: nou111

DOI: 10.1093/neuonc/nou111

PMC ID: 4201073

PubMed ID: 24951112

SO-VID: dee66664-dbcf-4fc7-be6a-f07d2deea42b

History

Keywords: Sp1,glioblastoma multiforme,invasion,miR-377,proliferation

Data availability:

Keywords: Sp1, glioblastoma multiforme, invasion, miR-377, proliferation

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