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      Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry

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          Abstract

          Introduction

          The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance.

          Methods

          Participants completed the Cogstate Brief Battery unsupervised at home.

          Results

          Data from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults ( P < .05 for all), and online cognitive test performance significantly improved diagnostic classification ( P < .001). Poorer performance on all cognitive measures was associated with memory concern ( P < .001 for all) but not family history of dementia.

          Discussion

          Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials.

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          Most cited references29

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          Clinical trial registration: a statement from the International Committee of Medical Journal Editors.

          Catherine De Angelis, Jeffrey M. Drazen, Frank Frizelle … (2004)
          Article 0 comments Cited 241 times – based on 0 reviews     Review now
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            Registering clinical trials.

            Drummond Rennie, Kay Dickersin (2003)
            That it is not possible to find information about all initiated clinical trials is of international concern. This is a particular worry because scientists tend to publish their positive findings more often than their negative findings (publication bias). A comprehensive register of initiated clinical trials, with each trial assigned a unique identifier, would inform reviewers, physicians, and others (eg, consumers) about which trials had been started and directly address the problem of publication bias. Patients and their clinicians could also know which trials are open for enrollment, thus speeding medical advances. Individuals who participate in clinical trials typically provide consent in the belief that they are contributing to medical knowledge. But if the knowledge gained is never reported, the trust between patients and investigators and that between patients and research ethics review boards are both damaged. Ethical issues are of particular concern if industry is gaining financially from public involvement in trials, but refusing to reciprocate by making information from industry-sponsored trials generally available. All stakeholders-investigators, research organizations and institutions, journal editors, lawmakers, consumers, and others-must act now, together and in their own domains, to ensure comprehensive registration of clinical trials.
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              Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.

              Shelli Kesler, S.M. Hadi Hosseini, Charles E Heckler … (2013)
              A majority of breast cancer (BC) survivors, particularly those treated with chemotherapy, experience long-term cognitive deficits that significantly reduce quality of life. Among the cognitive domains most commonly affected include executive functions (EF), such as working memory, cognitive flexibility, multitasking, planning, and attention. Previous studies in other populations have shown that cognitive training, a behavioral method for treating cognitive deficits, can result in significant improvements in a number of cognitive skills, including EF.
              Article 0 comments Cited 85 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                R. Scott Mackin
                Journal
                Journal ID (nlm-ta): Alzheimers Dement (Amst)
                Journal ID (iso-abbrev): Alzheimers Dement (Amst)
                Title: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
                Publisher: Elsevier
                ISSN (Electronic): 2352-8729
                Publication date PMC-release: 21 June 2018
                Publication date Collection: 2018
                Publication date (Electronic): 21 June 2018
                Volume: 10
                Pages: 573-582
                Affiliations
                [a ]Department of Psychiatry, University of California, San Francisco, CA, USA
                [b ]Center for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical Center, San Francisco, CA, USA
                [c ]Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
                [d ]Pfizer, USA
                [e ]Cogstate Inc, USA
                [f ]Department of Radiology, University of California, San Francisco, CA, USA
                Author notes
                [∗ ]Corresponding author. Tel.: 415 476 7067; Fax: 415 750 9358. Scott.Mackin@ 123456ucsf.edu
                Article
                Publisher ID: S2352-8729(18)30030-7
                DOI: 10.1016/j.dadm.2018.05.005
                PMC ID: 6215059
                PubMed ID: 30406176
                SO-VID: df245363-5273-4b19-b00d-5a3c2b113c74
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Categories
                Subject: Cognitive & Behavioral Assessment

                Keywords: brain health registry,online cognitive tests,internet,memory,attention,information-processing speed,research registry,dementia,mild cognitive impairment
                Data availability:
                Keywords: brain health registry, online cognitive tests, internet, memory, attention, information-processing speed, research registry, dementia, mild cognitive impairment

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