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      A Valuable Improvement of Adult Height Prediction Methods in Short Normal Children

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          Abstract

          Objectives: The potential benefit of growth hormone (GH) administration to increase adult height of normal children of short stature might be blurred by the accuracy and the precision of the prediction methods used to estimate final height before onset of therapy. The aim of the present study was to evaluate three prediction methods: Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT) and Tanner-Whitehouse Mark II (TW2) and to improve their accuracy and precision by exploring their correlation with various parameters obtained in peripubertal children with poor predicted adult height. Study Design: Accuracy and precision of the prediction methods were evaluated retrospectively by comparing predicted adult heights estimated in 62 boys at 13.7 ± 0.9 years and in 28 girls at 12.1 ± 0.9 years of age, with their adult heights measured respectively at 20.7 ± 2.6 years and 18.8 ± 2.8 years. Results: At the time of prediction, the height for chronological age was -2.07 ± 0.68 standard deviation scores for boys and -2.15 ± 0.6 years for girls. Measured adult heights were significantly lower than target heights (165.1 ± 5.1 vs. 169.4 ± 4.8 cm for boys; p < 0.001 and 153.1 ± 3.9 vs. 156.3 ± 5.0 cm for girls; p = 0.001). For boys, the BP method was the most accurate and also the most convenient with a predicted adult height of 164.7 ± 5.0 cm and a small underestimation of 0.4 ± 3.5 cm. For girls, the TW2 method was the most accurate with a predicted height of 152.4 ± 3.7 cm with a little underestimation of 0.7 ± 3.5 cm. There were no important differences between the precision of these methods. The use of a correction factor derived from the bone age delay at the time of prediction in boys and from the chronological age at the time of prediction in girls improved the accuracy of the predicted adult height. Conclusions: The use of a factor correcting the accuracy of the BP method in boys and of the TW2 method in girls should be valuable in assessing the potential benefit of GH therapy to increase adult height in short normal children.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1997
          1997
          10 December 2008
          : 48
          : 4
          : 184-190
          Affiliations
          Departments of Pediatrics, Universities of aLeuven, bAntwerp, cLiège, and dDepartment of Endocrinology, University of Ghent, Belgium
          Article
          185511 Horm Res 1997;48:184–190
          10.1159/000185511
          9378465
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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