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The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis.
Thomas Müller
1 ,
Bart van de Sluis ,
Alexandra Zhernakova ,
Ellen van Binsbergen ,
Andreas R Janecke ,
Ashish Bavdekar ,
Anand Pandit ,
Helga Weirich-Schwaiger ,
Heiko Witt ,
Helmut Ellemunter ,
Johann Deutsch ,
Helmut Denk ,
Wilfried Müller ,
Irmin Sternlieb ,
M Stuart Tanner ,
Cisca Wijmenga
Feb 2003
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Abstract
Non-Wilsonian hepatic copper toxicosis includes Indian childhood cirrhosis (ICC), endemic Tyrolean infantile cirrhosis (ETIC) and the non-Indian disease known as idiopathic copper toxicosis (ICT). These entities resemble the hepatic copper overload observed in livers of Bedlington terriers with respect to their clinical presentation and biochemical and histological findings. We recently cloned the gene causing copper toxicosis in Bedlington terriers, MURR1, as well as the orthologous human gene on chromosome 2p13-p16.